Potassium supplement ameliorates salt-induced haemostatic abnormalities in normotensive subjects
Potassium supplement ameliorates salt-induced haemostatic abnormalities in normotensive subjects
复制标题
钾补充剂可改善血压正常受试者由盐引起的止血异常
DOI：
10.1080/ac.66.5.2131090
复制
发表时间：
2011-10
影响因子：
1.6
通讯作者：
LIU fuqiang
中科院分区：
文献类型：
--
作者：
LIU fuqiang
研究背景膳食高盐或低钾总是与死亡或心血管并发症的发生率增加有关，但其机制仍不清楚。我们推测，止血异常可能发挥了重要作用的现象。方法选取北方某农村社区20名血压正常者，年龄25 ~ 50岁。所有受试者依次维持3天的基线调查，7天低盐饮食（每天51.3 mmol或3 g NaCl），7天高盐饮食（每天307.7 mmol或18 g NaCl），另外7天高盐饮食补充钾（4.5 g/天，KCl）。测定血浆中纤维蛋白原、D-二聚体和血管性血友病因子（vWF）的浓度，这些数据代表全身止血状态。结果高盐饮食组血浆纤维蛋白原、纤维蛋白D-二聚体和vWF水平显著高于低盐饮食组（P < 0.05）。补钾可使钠依赖性止血异常转为正常（P < 0.05）。结论膳食高盐摄入可刺激止血因子的产生，最终导致心血管事件的发生。补充钾可改善钠引起的止血异常。
Background Dietary high salt or low potassium is always associated with an increased incidence of death or cardiovascular complications, but the mechanisms remain elusive. We hypothesize that haemostatic abnormalities may play an important role in the phenomenon. Methods Twenty normotensive subjects (aged 25 to 50 years) were selected from a rural community of Northern China. All of the people were sequentially maintained on a 3-day baseline investigation, 7 days on a low-salt diet (51.3 mmol or 3 g of NaCl per day), 7 days on a high-salt diet (307.7 mmol or 18 g of NaCl per day), and another 7 days on a high-salt diet with potassium supplementation (4.5 g/day, KCl). The concentrations of fi brinogen, D-dimer and von Willebrand factor (vWF) in plasma were assessed, and these data represent the systemic haemostatic state. Results Plasma levels of fi brinogen, fi brin D-dimer and vWF were signifi cantly higher in the high-salt diet than in the low-salt diet (P < 0.05). In contrast, potassium supplement could convert the sodium-dependent haemostatic abnormalities to normal (P < 0.05). Conclusions Dietary high salt intake could stimulate the production of haemostatic factors, which may ultimately lead to cardiovascular events. Inversely, potassium supplementation could ameliorate the sodium-induced haemostatic abnormalities.
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影响因子：
--
作者：
Cook, Nancy R.;Obarzanek, Eva;Cutler, Jeffrey A.;Buring, Julie E.;Rexrode, Kathryn M.;Kumanyika, Shiriki K.;Appel, Lawrence J.;Whelton, Paul K.
通讯作者：
Whelton, Paul K.
影响因子：
120.7
作者：
Whelton, PK;He, J;Karimbakas, J
通讯作者：
Karimbakas, J
影响因子：
--
作者：
Ageno, W;Finazzi, S;Venco, A
通讯作者：
Venco, A
影响因子：
8.3
作者：
Nagata, C;Takatsuka, N;Shimizu, H
通讯作者：
Shimizu, H
DOI：
10.1097/00008483-200007000-00013
发表时间：
1999-12
期刊：
JAMA
影响因子：
--
作者：
Jiang He;L. Ogden;S. Vupputuri;L. Bazzano;C. Loria;P. Whelton
通讯作者：
Jiang He;L. Ogden;S. Vupputuri;L. Bazzano;C. Loria;P. Whelton