Glycan-protein interactions in viral pathogenesis.
Glycan-protein interactions in viral pathogenesis.
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DOI：
10.1016/j.sbi.2016.10.003
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发表时间：
2016-10
影响因子：
6.8
通讯作者：
Sasisekharan R
中科院分区：
文献类型：
--
作者：
Raman R;Tharakaraman K;Sasisekharan V;Sasisekharan R
复合聚糖在病毒与宿主的相互作用中起着多方面的作用。宿主聚糖充当病毒进入的辅助受体或特异性主要受体。病毒聚糖-宿主凝集素或抗体相互作用有利于病毒或宿主。本文综述了聚糖-蛋白质相互作用在病毒发病机制中的作用。病毒和宿主细胞的表面被复杂的聚糖修饰，它们在病毒与宿主的动态相互作用中起着多方面的作用，包括病毒进入宿主细胞、调节病毒蛋白的蛋白水解裂解、宿主免疫系统对病毒的识别和中和。这些作用由聚糖与其同源蛋白（通常称为聚糖结合蛋白或GBP或凝集素）的特异性多价相互作用介导。化学合成和结构表征聚糖和聚糖-GBP相互作用的工具和技术的进步为聚糖-GBP相互作用在病毒发病机制中的作用提供了一些见解，并为靶向这些相互作用提供了新的抗病毒治疗或疫苗策略的机会。本文综述了宿主细胞表面聚糖受体和病毒表面聚糖在病毒发病机制中的作用，并就如何利用各种分析工具来靶向聚糖-GBP相互作用提供了观点。
Complex glycans play multifaceted roles in interplay between virus and its host. Host glycans serve co-receptors or specific primary receptors for viral entry. Viral glycan – host lectin or antibody interaction favors either virus or host. This review covers role of glycan–protein interactions in viral pathogenesis. The surfaces of host cells and viruses are decorated by complex glycans, which play multifaceted roles in the dynamic interplay between the virus and the host including viral entry into host cell, modulation of proteolytic cleavage of viral proteins, recognition and neutralization of virus by host immune system. These roles are mediated by specific multivalent interactions of glycans with their cognate proteins (generally termed as glycan-binding proteins or GBPs or lectins). The advances in tools and technologies to chemically synthesize and structurally characterize glycans and glycan–GBP interactions have offered several insights into the role of glycan–GBP interactions in viral pathogenesis and have presented opportunities to target these interactions for novel antiviral therapeutic or vaccine strategies. This review covers aspects of role of host cell surface glycan receptors and viral surface glycans in viral pathogenesis and offers perspectives on how to employ various analytical tools to target glycan–GBP interactions.
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