HEMODYNAMIC REGULATION - INVESTIGATION BY SPECTRAL-ANALYSIS
HEMODYNAMIC REGULATION - INVESTIGATION BY SPECTRAL-ANALYSIS
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DOI：
10.1152/ajpheart.1985.249.4.h867
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发表时间：
1985-01-01
影响因子：
--
通讯作者：
COHEN, RJ
中科院分区：
文献类型：
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作者：
AKSELROD, S;GORDON, D;COHEN, RJ
我们研究了这样的假设：血流动力学参数的逐次变化反映了循环功能的持续扰动与短期心血管控制系统的补偿反应之间的动态相互作用。通过 0.02 至 1 Hz 频率范围内的频谱分析来分析心率 (HR)、动脉血压和呼吸的自发波动。提出了短期心血管控制的简单闭环模型，并在一系列实验中进行了评估：使用副交感神经、α-交感神经、β-交感神经和肾素-血管紧张素系统的药理学阻断来打开主要控制环路，以便检查波动的光谱模式的变化。心房起搏用于在没有心率变异性的情况下检查血压变异性。我们发现心率的呼吸频率波动是副交感神经介导的，并且该频率的血压波动几乎完全是由中枢介导的心率波动的直接影响造成的。交感神经系统似乎过于迟缓，无法调节呼吸频率的变化。 HR 的低频（0.02-0.09 Hz）波动由副交感神经和β-交感神经系统共同介导，并且似乎补偿了该频率下的血压波动。低频血压波动可能是由于血管舒缩活动的变化引起的，血管舒缩活动通常受到肾素-血管紧张素系统活动的抑制。然而，α-肾上腺素能系统的阻断不会显着改变低频血压波动。
We investigated the hypothesis that beat-to-beat variability in hemodynamic parameters reflects the dynamic interplay between ongoing perturbations to circulatory function and the compensatory response of shortterm cardiovascular control systems. Spontaneous fluctuations in heart rate (HR), arterial blood pressure, and respiration were analyzed by spectral analysis in the 0.02- to 1-Hz frequency range. A simple closed-loop model of short-term cardiovascular control was proposed and evaluated in a series of experiments: pharmacological blockades of the parasympathetic, .alpha.-sympathetic, .beta.-sympathetic, and renin-angiotensin systems were used to open the principal control loops in order to examine changes in the spectral pattern of the fluctuations. Atrial pacing was used to examine blood pressure variability in the absence of HR variability. We found that respiratory frequency fluctuations in HR are parasympathetically mediated and that blood pressure fluctuations at this frequency result almost entirely from the direct effect of centrally mediated HR fluctuations. The sympathetic nervous system appears to be too sluggish to mediate respiratory frequency variations. Low-frequency (0.02-0.09 Hz) fluctuations in HR are jointly mediated by the parasympathetic and .beta.-sympathetic systems and appear to compensate for blood pressure fluctuations at this frequency. Low-frequency blood pressure fluctuations are probably due to variability in vasomotor activity which is normally damped by renin-angiotensin system activity. Blockade of the .alpha.-adrenergic system, however, does not significantly alter low-frequency blood pressure fluctuations.