Adaptive protein evolution in Drosophila
Adaptive protein evolution in Drosophila
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DOI：
10.1038/4151022a
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发表时间：
2002-02-28
期刊：
影响因子：
64.8
通讯作者：
Eyre-Walker, A
中科院分区：
文献类型：
--
作者：
Smith, NGC;Eyre-Walker, A
30 多年来，分子进化的一个中心问题一直是自然选择是否在 DNA 序列水平的进化中发挥重要作用(1,2)。过去十年积累的证据表明适应性进化确实发生在蛋白质水平(3,4)，但适应性进化有多普遍仍不清楚。在这里，我们提出了一种简单的方法，可以估计自适应替换的数量，并将其应用于来自模拟果蝇和果蝇的数据。我们估计，45% 的氨基酸取代是通过自然选择固定的，这些物种平均每 45 年就会发生一次适应性取代。
For over 30 years a central question in molecular evolution has been whether natural selection plays a substantial role in evolution at the DNA sequence level(1,2). Evidence has accumulated over the last decade that adaptive evolution does occur at the protein level(3,4), but it has remained unclear how prevalent adaptive evolution is. Here we present a simple method by which the number of adaptive substitutions can be estimated and apply it to data from Drosophila simulans and D. yakuba. We estimate that 45% of all amino-acid substitutions have been fixed by natural selection, and that on average one adaptive substitution occurs every 45 years in these species.