Erythropoietin prevents cognition impairment induced by transient brain ischemia in gerbils
Erythropoietin prevents cognition impairment induced by transient brain ischemia in gerbils
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DOI：
10.1016/s0014-2999(02)01292-x
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发表时间：
2002-02-22
影响因子：
5
通讯作者：
Calapai, G
中科院分区：
文献类型：
--
作者：
Catania, MA;Marciano, MC;Calapai, G
促红细胞生成素在中枢神经系统（CNS）中的作用是近年来研究的热点。在不同的脑损伤模型中已显示出神经保护作用，我们研究了从减少短暂性脑缺血后神经元损失评估的神经保护作用是否与学习能力的保存有关。将重组人促红细胞生成素（0.5 ~ 25 U）注射到双侧颈动脉暂时性（3 min）闭塞的沙鼠侧脑室，进行缺血后CA1区神经元丢失组织学评价和被动回避试验。重组人促红细胞生成素治疗可显著减少海马CA1区的延迟性神经元死亡，并预防被动回避试验中的认知障碍。这些数据表明重组人促红细胞生成素在脑缺血中的神经保护作用与学习功能的保存有关。2002年由爱思唯尔科学有限公司出版
Erythropoietin has recently been studied for its role in the central nervous system (CNS). It has been shown to exert neuroprotective effects in different models of brain injury, We studied whether neuroprotective effects assessed from the reduction of neuronal loss after transient brain ischemia are associated to the preservation of learning ability. Recombinant human erythropoietin (0.5-25 U) was injected in the lateral cerebral ventricle of gerbils that are subjected to temporary (3 min) bilateral carotid occlusion, Post-ischemic histological evaluation of CA1 area neuronal loss and passive avoidance test were performed. Treatment with recombinant human erythropoietin significantly reduced delayed neuronal death in the CA1 area of the hippocampus and prevented cognition impairment in the passive avoidance test. These data indicate that recombinant human erythropoietin neuroprotective effects in brain ischemia are associated with the preservation of learning function. 0 2002 Published by Elsevier Science B.V.