Notch signaling as a target in multimodality cancer therapy.
Notch signaling as a target in multimodality cancer therapy.
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发表时间：
2000-02
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通讯作者：
Jang Ms;A. Zlobin;Kast Wm;L. Miele
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作者：
Jang Ms;A. Zlobin;Kast Wm;L. Miele
Notch信号传导是一种非常保守和广泛使用的控制细胞命运决定的机制。最近的证据表明，Notch受体调节许多细胞（包括肿瘤细胞）中的细胞分化、增殖和凋亡。在癌症实验性免疫治疗和多模式治疗的背景下，Notch信号网络因其在肿瘤细胞和免疫系统中的可能作用而变得越来越重要。在这篇综述中，我们讨论了：（i）Notch信号在癌细胞和免疫系统中的作用;（ii）Notch靶向生物制剂可用于提高多模式癌症治疗（包括癌症疫苗）的有效性的策略。
Notch signaling is an extremely conserved and widely used mechanism controlling cell fate determination. Recent evidence shows that Notch receptors regulate cell differentiation, proliferation and apoptosis in many cells, including neoplastic cells. In the context of cancer experimental immunotherapy and multimodality therapy, the Notch signaling network is acquiring increasing importance for its possible roles in both neoplastic cells and the immune system. In this review, we discuss: (i) the roles of Notch signaling in cancer cells and the immune system; and (ii) strategies through which Notch-targeting biologicals may be used to increase the effectiveness of multimodality cancer treatment, including cancer vaccines.