Oxaliplatin-Induced Neuropathy: Genetic and Epigenetic Profile to Better Understand How to Ameliorate This Side Effect.
Oxaliplatin-Induced Neuropathy: Genetic and Epigenetic Profile to Better Understand How to Ameliorate This Side Effect.
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奥沙利铂诱发的神经病变：遗传和表观遗传特征，以更好地了解如何改善这种副作用。
DOI：
10.3389/fmolb.2021.643824
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发表时间：
2021
影响因子：
5
通讯作者：
Pacini A
中科院分区：
文献类型：
--
作者：
Branca JJV;Carrino D;Gulisano M;Ghelardini C;Di Cesare Mannelli L;Pacini A
在最近的几十年里，奥沙利铂已被用作结直肠癌和其他恶性肿瘤的化疗药物。奥沙利铂主要通过DNA-铂加合物的形成来抑制DNA合成，进而导致癌细胞死亡，从而干扰肿瘤生长。另一方面，不幸的是，这种相互作用导致了过多的全身副作用，包括那些影响外周和中枢神经系统的副作用。奥沙利铂治疗与急性和慢性神经病理性疼痛有关，这种疼痛促使医生减少用药剂量或停止治疗。最近，奥沙利铂能够改变神经细胞的遗传和表观遗传学特征，了解基因表达和转录变化可能有助于寻找治疗神经病的新方法。本文旨在综述奥沙利铂对遗传和表观遗传机制的影响，以更好地了解如何减轻神经病理性疼痛，从而增强抗癌潜力，改善患者的生活质量。
In the most recent decades, oxaliplatin has been used as a chemotherapeutic agent for colorectal cancer and other malignancies as well. Oxaliplatin interferes with tumor growth predominantly exerting its action in DNA synthesis inhibition by the formation of DNA-platinum adducts that, in turn, leads to cancer cell death. On the other hand, unfortunately, this interaction leads to a plethora of systemic side effects, including those affecting the peripheral and central nervous system. Oxaliplatin therapy has been associated with acute and chronic neuropathic pain that induces physicians to reduce the dose of medication or discontinue treatment. Recently, the capability of oxaliplatin to alter the genetic and epigenetic profiles of the nervous cells has been documented, and the understanding of gene expression and transcriptional changes may help to find new putative treatments for neuropathy. The present article is aimed to review the effects of oxaliplatin on genetic and epigenetic mechanisms to better understand how to ameliorate neuropathic pain in order to enhance the anti-cancer potential and improve patients’ quality of life.