Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells
Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells
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DOI：
10.1016/j.abb.2007.05.018
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发表时间：
2007-08-15
影响因子：
3.9
通讯作者：
Kadlubar, Fred F.
中科院分区：
文献类型：
--
作者：
Ambrosone, Christine B.;Abrams, Sara M.;Kadlubar, Fred F.
饮食和环境暴露于芳香胺和杂环胺以及多环芳烃被认为是乳腺癌风险的病因因素。在这项研究中，我们选择对从人类母乳中分离的上皮细胞DNA中来自每一类致癌物的一种成员的主要DNA加合物进行量化。每类化合物均检测到了可察觉的加合物，即2-氨基-6-苯基咪唑并[4，5-b]吡啶(PhIP)、4-氨基联苯(ABP)和苯并[a]芘。还研究了几种代谢基因对加合物水平的影响，较高的PhIP和ABP加合物与快速的NAT2和/或快速的NAT1基因相关。ABP加合物的存在也与染发产品的使用显著相关(OR=11.2，95%CI=1.1-109.2)，但与烟草的使用无关。这些数据表明，妇女暴露在几类饮食和环境致癌物质中，代谢基因可能是一个易感因素。(C)2007 Elsevier Inc.保留所有权利。
Diet and environmental exposures to aromatic and heterocyclic amines, and polycyclic aromatic hydrocarbons, are thought to be etiologic factors for breast cancer risk. In this study, we chose to quantify the major DNA adduct derived from one member of each of these classes of carcinogens in epithelial cell DNA isolated from human breast milk. Appreciable adducts were detected for each class, namely 2-amino-6-phenylimidazo[4,5-b]pyridine (PhIP), 4-aminobiphenyl (ABP) and benzo[a]pyrene. The effect of several metabolic genotypes on adduct levels were also investigated and higher PhIP and ABP adducts were associated with the rapid NAT2 and/or rapid NAT1 genotypes. The presence of ABP adducts was also significantly associated with the use of hair coloring products (OR = 11.2, 95% Cl = 1.1-109.2) but not tobacco usage. These data indicate that women are exposed to several classes of dietary and environmental carcinogens and that metabolic genotype can be a susceptibility factor. (c) 2007 Elsevier Inc. All rights reserved.