Tissue microarray analysis reveals the expression and prognostic significance of phosphorylated AktThr308 in oral squamous cell carcinoma
Tissue microarray analysis reveals the expression and prognostic significance of phosphorylated AktThr308 in oral squamous cell carcinoma
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DOI：
10.1016/j.oooo.2013.06.031
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发表时间：
2013-11-01
影响因子：
2.9
通讯作者：
Chen, Qianming
中科院分区：
文献类型：
--
作者：
Li, Yanzhong;Wang, Jing;Chen, Qianming
目标.我们的目的是研究磷酸化Akt（Thr 308）（p-Akt（Thr 308））在口腔鳞状细胞癌（OSCC）组织中的表达与OSCC患者的临床病理参数之间的关系，并验证p-Akt（Thr 308）作为预后生物标志物的有效性。191例口腔鳞状细胞癌患者被招募参加这项研究。采用组织芯片免疫组化法检测p-Akt（Thr 308）的表达，并采用数字病理分析软件进行分析。所有患者均随访观察其临床病理参数。P-Akt（Thr 308）在95.2%的OSCC患者中表达。p-Akt（Thr 308）的表达与局部复发和5年生存率显著相关。p-Akt（Thr 308）在口腔鳞癌中的高表达与口腔鳞癌的恶性程度有关。P-Akt（Thr 308）可能是预测OSCC预后的候选生物标志物。
Objectives. We aimed to investigate the association between the expression of phosphorylated Akt(Thr308) (p-Akt(Thr308)) in oral squamous cell carcinoma (OSCC) tissues and clinicopathological parameters of OSCC patients and to verify the validity of p-Akt(Thr308) as a prognostic biomarker.Study design. One hundred and ninety-one patients with OSCC were recruited for the study. We tested the expression of p-Akt(Thr308) by immunohistochemistry (IHC) with tissue microarray (TMA) and analyzed with digital pathology analysis software. The clinicopathological parameters of all patients were collected from follow-up.Results. P-Akt(Thr308) was detected in 95.2% of OSCC patients. The expression of p-Akt(Thr308) was significantly correlated with local recurrence and five-year survival rate. High expression of p-Akt(Thr308) in OSCC was associated with poor prognosis.Conclusion. P-Akt(Thr308) might be a candidate biomarker for the prediction of OSCC prognosis.