Structural Changes in Hippocampal Subfields in Patients with Continuous Remission of Drug-Naive Major Depressive Disorder
Structural Changes in Hippocampal Subfields in Patients with Continuous Remission of Drug-Naive Major Depressive Disorder
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DOI：
10.3390/ijms21093032
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发表时间：
2020-05-01
影响因子：
5.6
通讯作者：
Yoshimura, Reiji
中科院分区：
文献类型：
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作者：
Katsuki, Asuka;Watanabe, Keita;Yoshimura, Reiji
目的：与健康对照组相比，重度抑郁障碍(MDD)患者的海马区体积缩小。海马体是一种边缘结构，在MDD中起着关键作用。本研究的目的是研究抗抑郁药物有效并持续缓解的MDD患者海马区及其亚区体积的变化。对象和方法：符合DSM-IV-TRMDD诊断标准，药物初治至少8周，汉密尔顿抑郁量表(HAMD)17项评分14分以上，抗抑郁治疗有效8周内，持续缓解6个月以上的患者18例。所有参与者都接受了T1加权结构磁共振成像，并接受了8周以上的抗抑郁药物治疗。我们比较了应答者在基线时和6个月时的海马体体积，包括它的亚区。用Freesurfer V6.0软件测量整个海马区和海马区的体积。结果：治疗6个月后，左侧杏仁核(CA)3(p=0.016)和齿状回颗粒细胞层(GC-DG)的体积较治疗前显著增加(p=0.021)。结论：在缓解至少6个月的MDD患者中观察到体积的增加。
Objective: Hippocampal volume is reduced in patients with major depressive disorder (MDD) compared with healthy controls. The hippocampus is a limbic structure that has a critical role in MDD. The aim of the present study was to investigate the changes in the volume of the hippocampus and its subfields in MDD patients who responded to antidepressants and subsequently were in continuous remission. Subjects and Methods: Eighteen patients who met the following criteria were enrolled in the present study: the DSM-IV-TR criteria for MDD, drug-naive at least 8 weeks or more, scores on the 17-items of Hamilton Rating Scale for Depression (HAMD) of 14 points or more, and antidepressant treatment response within 8 weeks and continuous remission for at least 6 months. All participants underwent T1-weighted structural MRI and were treated with antidepressants for more than 8 weeks. We compared the volumes of the hippocampus, including its subfields, in responders at baseline to the volumes at 6 months. The volumes of the whole hippocampus and the hippocampal subfields were measured using FreeSurfer v6.0. Results: The volumes of the left cornu Ammonis (CA) 3 (p = 0.016) and the granule cell layer of the dentate gyrus (GC-DG) region (p = 0.021) were significantly increased after 6 months of treatment compared with those at baseline. Conclusions: Increases in volume was observed in MDD patients who were in remission for at least 6 months.