Assessment of infant brain development with frequency-domain near-infrared spectroscopy
Assessment of infant brain development with frequency-domain near-infrared spectroscopy
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DOI：
10.1203/pdr.0b013e318045be99
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发表时间：
2007-05-01
影响因子：
3.6
通讯作者：
Grant, P. Ellen
中科院分区：
文献类型：
--
作者：
Franceschini, Maria Angela;Thaker, Sonal;Grant, P. Ellen
这是第一份报告，以证明定量监测婴儿大脑发育的频域近红外光谱（FD-NIRS）。在健康婴儿的第一年中，测量了血容量和耗氧量的区域特异性增加。结果与之前的PET和SPECT报告一致;但是，与这些方法不同，FD-NIRS是便携式的，并且使用非电离辐射。此外，新的信息包括随着年龄和位置的相对恒定的组织氧合，这表明在大脑发育期间，健康婴儿的局部氧气输送和消耗之间存在严格的控制。FD-NIRS可成为定量评估婴儿脑发育的首选临床工具。
This is the first report to demonstrate quantitative monitoring of infant brain development with frequency-domain near-infrared spectroscopy (FD-NIRS). Regionally specific increases in blood volume and oxygen consumption were measured in healthy infants during their first year. The results agree with prior PET and SPECT reports; but, unlike these methods, FD-NIRS is portable and uses nonionizing radiation. Further, new information includes the relatively constant tissue oxygenation with age and location, suggesting a tight control between local oxygen delivery and consumption in healthy infants during brain development. FD-NIRS could become the preferred clinical tool for quantitatively assessing infant brain development.