The prognostic value of multiorgan metastases in patients with non-small cell lung cancer and its variants: a SEER-based study
The prognostic value of multiorgan metastases in patients with non-small cell lung cancer and its variants: a SEER-based study
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非小细胞肺癌及其变异体患者多器官转移的预后价值：一项基于 SEER 的研究
DOI：
10.1007/s00432-018-2702-9
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发表时间：
2018-09-01
影响因子：
3.6
通讯作者：
Huang, Yueye
中科院分区：
文献类型：
--
作者：
Yang, Jie;Zhang, Yuan;Huang, Yueye
目的本研究旨在探讨不同器官转移对非小细胞肺癌（NSCLC）及其最常见亚型患者的预后价值（25，129名男性和20，294名女性）在2010年至2013年期间发生远处转移，并从监测，流行病学，结果骨转移和肝转移分别占37.1%和16.8%，是最常见和最不常见的转移部位。与骨、脑、肝、肺转移和多器官转移（MDR）相关的死亡率分别为73.2%、72.7%、78.3%、65.4%和77.5%。Kaplan-Meier分析显示，合并肝转移的患者生存率最低。与有其他器官转移但无四个器官转移的NSCLC病例相比，肺、骨、脑、肝转移和肺转移的风险比（HR）为0.906（95% CI 0.866-0.947）、1.276（95% CI 1.225-1.330）、1.318（95% CI 1.260-1.379）、1.481（95% CI 1.388-1.580）和1.647（95% CI 1.587-1.709）。结论非小细胞肺癌（NSCLC）和腺癌（AD）的死亡危险性最高，其次是骨、脑、其他器官和肺转移，AD是NSCLC最常见的变异型。这些结果将有助于对NSCLC患者的预后进行治疗前评估。
Purpose This study aimed to investigate the prognostic value of different organs metastases in patients with non-small cell lung cancer (NSCLC) and its most common subtypes.Methods We identified 45,423 NSCLC cases (25,129 men and 20,294 women) between 2010 and 2013 with distant metastases, with complete clinical information obtained from the surveillance, epidemiology, and end results (SEER) database.Results Bone and liver were the most and the least common metastatic sites with rates of 37.1 and 16.8%, respectively. The mortality rates associated with bone, brain, liver, lung metastases, and multiorgan metastases (MOM) were 73.2, 72.7, 78.3, 65.4, and 77.5%, respectively. Kaplan-Meier analyses demonstrated that patients with MOM and liver metastasis had the worst survival. Compared with NSCLC cases with other organ metastasis, but without the four organs metastasis, hazard ratios (HRs) for lung, bone, brain, and liver metastases, and MOM were 0.906 (95% CI 0.866-0.947), 1.276 (95% CI 1.225-1.330), 1.318 (95% CI 1.260-1.379), 1.481 (95% CI 1.388-1.580), and 1.647 (95% CI 1.587-1.709), respectively. Similar results were obtained for adenocarcinoma (AD) cases.Conclusions The mortality risk is highest with MOM and liver metastasis followed by bone, brain, other organ, and lung metastases in NSCLC and AD which is the most common variant for NSCLC. These results will be helpful for pre-treatment evaluation regarding the prognosis of NSCLC patients.