Association study of schizophrenia with dopamine D3 receptor gene polymorphisms: probable effects of family history of schizophrenia?
Association study of schizophrenia with dopamine D3 receptor gene polymorphisms: probable effects of family history of schizophrenia?
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精神分裂症与多巴胺 D3 受体基因多态性的关联研究：精神分裂症家族史的可能影响？
DOI：
10.1002/ajmg.1320480408
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Chakravarti,A
中科院分区：
文献类型：
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作者：
Nimgaonkar,VL;Zhang,XR;Caldwell,JG;Ganguli,R;Chakravarti,A
采用病例对照设计，研究了一组精神分裂症患者（n = 53）、精神分裂症患者（DSM - III - R）和精神正常对照组（n = 61）中多巴胺D3受体基因位点纯合性与精神分裂症的关联，这些患者的种族和居住地区相匹配。两组间等位基因和基因型分布无显著差异。然而，在有精神分裂症家族史的患者中，与没有家族史的对照组相比，该位点与等位基因1存在关联（优势比12.4，比值比1.61，比值比96.35）。©1993 Wiley‐Liss, Inc。
Using a case‐control design, a reported association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus was investigated in a group of patients (n = 53), with schizophrenia (DSM‐III‐R), and psychiatrically normal controls (n = 61), matched for ethnicity and area of residence. No significant differences in the distribution of alleles or genotypes between the two groups could be deteched. However, among patients with a family history of schizophrenia, as compared to controls without such family history, an association with allele 1 at this locus was noted (Odds ratio 12.4, C.I. 1.61, 96.35). © 1993 Wiley‐Liss, Inc.