F-2-Methyl-2-pentanol. An easily prepared perfluorinated tertiary alcohol
F-2-Methyl-2-pentanol. An easily prepared perfluorinated tertiary alcohol
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DOI：
10.1021/jo00324a033
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发表时间：
1981
影响因子：
3.6
通讯作者：
K. Scherer;T. F. Terranova;D. Lawson
中科院分区：
文献类型：
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作者：
K. Scherer;T. F. Terranova;D. Lawson
6 1 (a) KF，18-冠-6，乙腈，10-15℃。(b)KF，18-冠-6，二甲基乙酰胺，回流，(c)KF，NOCl或N20N，二甲基乙酰胺，约0℃。(d)O2或N2O4在室温下，(e)，廉价的起始材料和常用试剂。氟化醇，特别是2, 2, 2-三氟乙醇和2H-F-2-丙醇（六氟-2-丙醇）作为特种溶剂引起了人们的关注，因为它们具有低亲核性、强大的氢键供体能力、3和全氟叔醇作为一类应具备的这些品质以及优异的化学不反应性。F-叔丁醇（2）是唯一市售的全氟醇，但几乎没有受到关注。由于其高价格和适中的液体范围（-15 至 + 45 C）而作为溶剂受到关注；它是通过 CsF-H2O, 4 与卤素 ex- 催化的 F-丙酮歧化制备的。
6 1 (a) KF, 18-crown-6, acetonitrile, 10-15 C.(b) KF, 18-crown-6, dimethylacetamide, reflux,(c) KF, NOCI or N20 „, dimethylacetamide, ca. 0 C.(d) 02 or N204 at room temperature,(e),. inexpensive starting material and common reagents. Fluorinated alcohols, particularly 2, 2, 2-trifluoroethanoland 2H-F-2-propanol (hexafluoro-2-propanol), have attracted attention as specialty solvents, owing to their low nu-cleophilicity, 2 powerful H-bond donor ability, 3 and optical transparency. Perfluorinated tertiary alcohols as a class should possess those qualities as well as exceptional chemical unreactivity.F-fert-Butanol (2), the only commercially available perfluorinated alcohol, has received little attention as a solvent because of its high priceand modest liquid range (-15 to+ 45 C); it has beenprepared by disproportionation of F-acetone catalyzed by CsF-H20, 4 by halogen ex-