Astrocytes give rise to new neurons in the adult mammalian hippocampus
Astrocytes give rise to new neurons in the adult mammalian hippocampus
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DOI：
10.1523/jneurosci.21-18-07153.2001
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发表时间：
2001-09-15
影响因子：
5.3
通讯作者：
Alvarez-Buylla, A
中科院分区：
文献类型：
--
作者：
Seri, B;García-Verdugo, JM;Alvarez-Buylla, A
海马齿状回中的神经发生在许多脊椎动物（包括人类）的一生中持续存在。这些新神经元的祖细胞位于齿状回的颗粒下层（SGL）。虽然已经从成年哺乳动物海马中培养出了能够自我更新并产生新的神经元和神经胶质的干细胞，但尚未鉴定出用于形成新神经元的体内初级前体。在这里，我们表明，SGL细胞，表达胶质细胞酸性蛋白和星形胶质细胞的特性，分裂和产生新的神经元在正常条件下或化学去除活跃分裂细胞后。我们还描述了一个人口的小电子致密SGL细胞，我们称之为D型细胞，来自星形胶质细胞和可能作为一个短暂的前体在新的神经元的形成。这些结果揭示了成年海马中新神经元的起源。
Neurogenesis in the dentate gyrus of the hippocampus persists throughout life in many vertebrates, including humans. The progenitors of these new neurons reside in the subgranular layer (SGL) of the dentate gyrus. Although stem cells that can self-renew and generate new neurons and glia have been cultured from the adult mammalian hippocampus, the in vivo primary precursors for the formation of new neurons have not been identified. Here we show that SGL cells, which express glial fibrillary acidic protein and have the characteristics of astrocytes, divide and generate new neurons under normal conditions or after the chemical removal of actively dividing cells. We also describe a population of small electron-dense SGL cells, which we call type D cells and are derived from the astrocytes and probably function as a transient precursor in the formation of new neurons. These results reveal the origins of new neurons in the adult hippocampus.