Reversible hypertension caused by calcium overloading in a patient with postoperative hypoparathyroidism.
Reversible hypertension caused by calcium overloading in a patient with postoperative hypoparathyroidism.
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术后甲状旁腺功能减退症患者因钙超载引起的可逆性高血压。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
S. Azukizawa
中科院分区：
文献类型：
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作者：
I. Yamamoto;S. Morimoto;K. Uchida;H. Hosojima;T. Kakita;T. Kigoshi;S. Azukizawa
1例37岁女性术后甲状旁腺功能减退症患者有高血压，在维生素D和过量补钙引起的两个月的高钙期内，血浆肾素活性(PRA)升高和随后的高醛固酮血症。然而，PRA升高的高血压患者对血管紧张素II(AII)类似物[Sar1，Ile8]ALL具有抵抗力。[Sar1，Ile8]ALL使PRA进一步升高，血浆醛固酮降低。当患者血钙正常、血压正常、血糖正常时，静脉滴注葡萄糖酸钙(5 mg钙/kg/h)1h。钙输注通过增加总外周阻力来复制高钙血压性高血压。这些观察表明，服用维生素D和过量钙补充剂时观察到的高血压可能是由钙对周围血管的直接作用引起的，肾素-血管紧张素系统可能起到微不足道的作用。
A 37-year-old woman with postoperative hypoparathyroidism had hypertension, and elevated plasma renin activity (PRA) and subsequent hyperaldosteronism during a two-month hypercalcemic period caused by vitamin D and excessive calcium supplements. The hypertension with elevated PRA, however, was resistant to the angiotensin II (AII) analog [Sar1, Ile8] ALL. PRA further increased and plasma aldosterone decreased in response to the [Sar1, Ile8] ALL. When the patient became normocalcemic, normotensive and normoreninemic, calcium gluconate (5 mg calcium/kg/h) was infused for one hour. The calcium infusion reproduced hypercalcemic hypertension mediated by an increase in total peripheral resistance. These observations suggest that the hypertension observed while taking vitamin D and excessive calcium supplements may be caused by a direct effect of calcium on peripheral blood vessels and the renin-angiotensin system may play a negligible role.