Comorbidities and Quality of Life among Breast Cancer Survivors: A Prospective Study
Comorbidities and Quality of Life among Breast Cancer Survivors: A Prospective Study
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DOI：
10.3390/jpm5030229
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发表时间：
2015-09-01
影响因子：
--
通讯作者：
Melkus, Gail D'Eramo
中科院分区：
文献类型：
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作者：
Fu, Mei R.;Axelrod, Deborah;Melkus, Gail D'Eramo
许多乳腺癌幸存者在诊断癌症时患有并存的慢性疾病或合并症。该研究的目的是评估合并症与乳腺癌幸存者生活质量的关联。采用前瞻性设计招募了 140 名癌症手术前的女性，其中 134 名女性完成了研究。癌症手术前和术后 12 个月，通过自我报告评估合并症，并通过病历审查和查尔森合并症指数 (CCI) 进行验证。使用简短健康调查 (SF-36 v2) 评估生活质量。数据分析采用描述性统计、卡方检验、t 检验、Fisher 精确检验和相关性。总共发现了 28 种合并症。在 134 名患者中，73.8% 的患者至少患有一种合并症，54.7% 的患者患有 2-4 种合并症，只有 7.4% 的患者患有 5-8 种合并症。术后 12 个月合并症没有变化。患者自我报告的合并症数量和 CCI 对合并症的加权分类与总体生活质量评分以及一般健康、身体功能、身体疼痛和活力等领域具有类似的负相关关系。合并症，特别是高血压、关节炎和糖尿病，与乳腺癌幸存者多个领域的生活质量较差有关。未来的研究应考虑合并症和癌症对患者生活质量的综合影响。
Many breast cancer survivors have coexistent chronic diseases or comorbidities at the time of their cancer diagnosis. The purpose of the study was to evaluate the association of comorbidities on breast cancer survivors' quality of life. A prospective design was used to recruit 140 women before cancer surgery, 134 women completed the study. Comorbidities were assessed using self-report and verified by medical record review and the Charlson Comorbidity Index (CCI) before and 12-month after cancer surgery. Quality of life was evaluated using Short-Form Health Survey (SF-36 v2). Descriptive statistics, chi-square tests, t-tests, Fisher's exact test, and correlations were performed for data analysis. A total of 28 comorbidities were identified. Among the 134 patients, 73.8% had at least one of the comorbidities, 54.7% had 2-4, and only 7.4% had 5-8. Comorbidities did not change at 12 months after surgery. Numbers of comorbidities by patients' self-report and weighted categorization of comorbidities by CCI had a similar negative correlation with overall quality of life scores as well as domains of general health, physical functioning, bodily pain, and vitality. Comorbidities, specifically hypertension, arthritis, and diabetes, were associated with poorer quality of life in multiple domains among breast cancer survivors. Future research should consider the combined influence of comorbidity and cancer on patients' quality of life.