The i-motif in nucleic acids
The i-motif in nucleic acids
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DOI：
10.1016/s0959-440x(00)00091-9
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发表时间：
2000-06-01
影响因子：
6.8
通讯作者：
Leroy, JL
中科院分区：
文献类型：
--
作者：
Guéron, M;Leroy, JL
在发现DNA i基序七年后，其发生的部分解释已经被发现，可能涉及CH。O氢键穿过狭窄的凹槽。它的生物学意义的调查一直鼓励的演示和描述的人端粒和着丝粒序列的分子内的i-基序结构，最近观察到的插入RNA结构和发现的蛋白质，与DNA序列携带胞嘧啶重复。嵌入与肽和硫代磷酸酯DNA类似物的相容性有利于可能的药物应用。
Seven yeats after the discovery of the DNA i-motif, partial explanations for its occurrence have been uncovered, possibly involving CH...O hydrogen bonds across the narrow grooves. Investigations of its biological significance have been encouraged by the demonstration and description of the intramolecular i-motif structure of human telomeric and centromeric sequences, by the recent observation of an intercalated RNA structure and by the discovery of proteins that associate with DNA sequences carrying cytosine repeats. The compatibility of the intercalation with peptide and phosphorothioate DNA analogs is favorable for possible pharmaceutical applications.