Ki-67 expression is predictive of prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasaltype
Ki-67 expression is predictive of prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasaltype
复制标题
DOI：
10.1093/annonc/mdm183
复制
发表时间：
2007-08-01
影响因子：
50.5
通讯作者：
Kim, J. S.
中科院分区：
文献类型：
--
作者：
Kim, S. J.;Kim, B. S.;Kim, J. S.
背景：局限性结外自然杀伤（NK）/T细胞淋巴瘤，鼻型，国际预后指数（IPI）通常具有低或中低风险，因此IPI在预测预后方面表现出不一致。因此，我们分析了 Ki-67 表达，并提出了一个新的预后模型，其中包括 1/11 期结外 NK/T 细胞淋巴瘤的 Ki-67 表达。 患者和方法：我们研究了 50 名结外 NK/T 细胞淋巴瘤患者的 Ki-67 表达及其与预后的关系。 结果：根据中值将患者分为：低 Ki-67（< 65%）与高 Ki-67（>= 65%）。高 Ki-67 与较差的总生存期（OS；P = 0.021）和无病生存期（DFS；P = 0.044）相关。多变量分析发现，Ki-67 表达和主要受累部位是 OS 和 DFS 的独立预后因素（P < 0.05）。基于这些结果，我们提出了一种具有 Ki-67 表达和主要受累部位的新临床病理预后模型。它与较差的 OS 和 DFS 高度相关（P < 0.001）。 结论：Ki-67 表达可预测预后，我们的预后模型可能成为预测 1/11 期鼻型结外 NK/T 细胞淋巴瘤患者预后的有用工具。
Background: Localized extranodal natural killer (NK)/T-cell lymphoma, nasal type, commonly has a low or low-intermediate risk of the international prognostic index (IPI), so the IPI has shown inconsistency in predicting prognosis. Thus, we analyzed Ki-67 expression and proposed a new prognostic model including Ki-67 expression for stage 1/11 extranodal NK/T-cell lymphoma.Patients and methods: We studied Ki-67 expression and its relationship with prognosis in 50 patients with extranodal NK/T-cell lymphoma.Results: The patients were dichotomized by the median value: low (< 65%) versus high Ki-67 (>= 65%). High Ki-67 was associated with a worse overall survival (OS; P = 0.021) and disease-free survival (DFS; P = 0.044). In multivariate analysis, Ki-67 expression and primary site of involvement were found to be an independent prognostic factor for OS and DFS (P < 0.05). Based on these results, we proposed a new clinico-pathological prognostic model with Ki-67 expression and the primary site of involvement. It showed a high degree of correlation with worse OS and DFS (P < 0.001).Conclusions: Ki-67 expression is predictive of prognosis, and our prognostic model may become a useful tool for predicting prognosis in patients with stage 1/11 extranodal NK/T-cell lymphoma, nasal type.