The Nucleoskeleton: Crossroad of Mechanotransduction in Skeletal Muscle.
The Nucleoskeleton: Crossroad of Mechanotransduction in Skeletal Muscle.
复制标题
核骨骼：骨骼肌机械转导的十字路口。
DOI：
10.3389/fphys.2021.724010
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发表时间：
2021
影响因子：
4
通讯作者：
Lovering RM
中科院分区：
文献类型：
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作者：
Iyer SR;Folker ES;Lovering RM
中间纤维是贯穿肌细胞的细胞骨架的主要结构成分(肌纤维)。机械转导是将机械力转化为生化信号以激活下游细胞反应的过程，对肌纤维的功能至关重要。机械力也作用于核细胞骨架，通过核骨架和细胞骨架(LINC)复合体的连接物与肌纤维细胞骨架结合。因此，原子核是力通过细胞传递的终点。核膜是位于核膜和染色质之间的致密网状结构，在响应机械输入方面起着至关重要的作用；肌纤维通过激活特定基因的信号通路不断地对机械干扰做出反应。细胞核是细胞中最大的细胞器，也是细胞内稳态的主要调节器，因此了解它对机械环境的反应是非常有意义的。由于骨骼肌细胞的合胞性和肌肉收缩所造成的极端机械环境，细胞核在骨骼肌细胞中的重要性被放大。在这篇综述中，我们总结了核骨架的组织和骨骼肌的收缩特征之间的双向联系，因为它们与肌肉功能有关。
Intermediate filaments (IFs) are a primary structural component of the cytoskeleton extending throughout the muscle cell (myofiber). Mechanotransduction, the process by which mechanical force is translated into a biochemical signal to activate downstream cellular responses, is crucial to myofiber function. Mechanical forces also act on the nuclear cytoskeleton, which is integrated with the myofiber cytoskeleton by the linker of the nucleoskeleton and cytoskeleton (LINC) complexes. Thus, the nucleus serves as the endpoint for the transmission of force through the cell. The nuclear lamina, a dense meshwork of lamin IFs between the nuclear envelope and underlying chromatin, plays a crucial role in responding to mechanical input; myofibers constantly respond to mechanical perturbation via signaling pathways by activation of specific genes. The nucleus is the largest organelle in cells and a master regulator of cell homeostasis, thus an understanding of how it responds to its mechanical environment is of great interest. The importance of the cell nucleus is magnified in skeletal muscle cells due to their syncytial nature and the extreme mechanical environment that muscle contraction creates. In this review, we summarize the bidirectional link between the organization of the nucleoskeleton and the contractile features of skeletal muscle as they relate to muscle function.
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影响因子：
3.3
作者：
Iyer, Shama R.;Shah, Sameer B.;Lovering, Richard M.
通讯作者：
Lovering, Richard M.
影响因子：
3.3
作者：
Giacomini C;Mahajani S;Ruffilli R;Marotta R;Gasparini L
通讯作者：
Gasparini L
影响因子：
3.9
作者：
Iyer SR;Hsia RC;Folker ES;Lovering RM
通讯作者：
Lovering RM
影响因子：
4
作者：
Bertrand, Anne T.;Ziaei, Simindokht;Coirault, Catherine
通讯作者：
Coirault, Catherine
孤立的细胞核适应力并揭示了细胞核中的力传导途径。
影响因子：
21.3
作者：
通讯作者：
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