Optimal vortex formation as an index of cardiac health
Optimal vortex formation as an index of cardiac health
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DOI：
10.1073/pnas.0600520103
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发表时间：
2006-04-18
影响因子：
11.1
通讯作者：
Dabiri, JO
中科院分区：
文献类型：
--
作者：
Gharib, M;Rambod, E;Dabiri, JO
心脏病仍然是世界范围内的主要死亡原因。先前的研究表明，心脏左心室（LV）舒张充盈期间的动力学可能在决定整体心脏健康方面发挥关键作用。因此，许多研究旨在基于描述LV功能的定量参数来预测和评估全球心脏健康。然而，左心室舒张在其电、肌肉和血液动力学过程中的固有复杂性阻碍了在纠正措施最有效的早期阶段准确预测和诊断心力衰竭的工具的开发。在这项工作中，它表明，心脏功能的主要方面反映了独特的和敏感的优化涡流形成的血流在早期的心脏，测量无量纲的数值指数。该最佳涡流形成指数与心脏健康的现有测量（例如LV射血分数）相关性良好。然而，与现有的措施，这种以前未描述的指数不需要患者的具体信息，以确定对应于正常功能的指数数值。对人类受试者的正常和病理心脏健康的研究表明，该全球指数能够通过对无创LV测量的直接分析来区分疾病状态。
Heart disease remains a leading cause of death worldwide. Previous research has indicated that the dynamics of the cardiac left ventricle (LV) during diastolic filling may play a critical role in dictating overall cardiac health. Hence, numerous studies have aimed to predict and evaluate global cardiac health based on quantitative parameters describing LV function. However, the inherent complexity of LV diastole, in its electrical, muscular, and hemodynamic processes, has prevented the development of tools to accurately predict and diagnose heart failure at early stages, when corrective measures are most effective. In this work, it is demonstrated that major aspects of cardiac function are reflected uniquely and sensitively in the optimization of vortex formation in the blood flow during early diastole, as measured by a dimensionless numerical index. This index of optimal vortex formation correlates well with existing measures of cardiac health such as the LV ejection fraction. However, unlike existing measures, this previously undescribed index does not require patient-specific information to determine numerical index values corresponding to normal function. A study of normal and pathological cardiac health in human subjects demonstrates the ability of this global index to distinguish disease states by a straightforward analysis of noninvasive LV measurements.