IONIC PERMEABILITY OF INHIBITORY POSTSYNAPTIC MEMBRANE OF LOBSTER MUSCLE FIBERS
IONIC PERMEABILITY OF INHIBITORY POSTSYNAPTIC MEMBRANE OF LOBSTER MUSCLE FIBERS
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DOI：
10.1085/jgp.54.4.437
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发表时间：
1969-01-01
影响因子：
3.8
通讯作者：
GRUNDFEST, H
中科院分区：
文献类型：
--
作者：
MOTOKIZAWA, F;REUBEN, JP;GRUNDFEST, H
在不同离子条件下，用细胞内记录法测定了龙虾肌纤维的抑制性突触后电位（EIPSP）和膜静息电位（EM）。在电化学梯度上，细胞内Cl（Cli）的“移动的”部分显著小于总细胞内Cl。活性抑制膜对某些“外来”阴离子的渗透性更强，顺序为NO3> SCN > Br > Cl。膜对BrO、羟乙基磺酸盐和甲基硫酸盐是不可渗透的，但对乙酸盐和丙酸盐是轻微可渗透的。Clis的水平似乎部分取决于一些活动（泵？）过程和大多数研究的阴离子出现干扰稳态水平的氯。
Reversal potentials (EIPSP) of the inhibitory postsynaptic potential and the membrane resting potentials (EM) of lobster muscle fibers were determined with intracellular recording under a variety of ionic conditions.EIPSPis solely dependent on the electromotive force of anionic batteries; i.e., on the electrochemical gradient for a "mobile" fraction of intracellular Cl (Cli) which is considerably smaller than the total intracellular Cl. The active inhibitory membrane is more permeable to certain "foreign" anions in the order NO3> SCN > Br > Cl. The membrane is impermeable to BrOs, isethionate, and methylsulfate, but is slightly permeable to acetate and propionate. The level of Cliappears to be determined in part by some active (pump?) process and most of the anions studied appear to interfere with the steady-state level of Cli.