Parsing the neural correlates of anxious apprehension and anxious arousal in the grey-matter of healthy youth
Parsing the neural correlates of anxious apprehension and anxious arousal in the grey-matter of healthy youth
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DOI：
10.1007/s11682-017-9772-1
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发表时间：
2018-08-01
影响因子：
3.2
通讯作者：
Greening, Steven G.
中科院分区：
文献类型：
--
作者：
Castagna, Peter J.;Roye, Scott;Greening, Steven G.
神经科学和心理学研究认为，焦虑有两个跨诊断方面：焦虑唤醒和焦虑恐惧。虽然焦虑的这两个方面是不同的，但它们通常被归入一个领域（例如，特质焦虑）。本研究的主要目标是描绘焦虑唤醒和皮质厚度之间的关系与焦虑的忧虑和皮质厚度之间的关系，在一个样本的典型功能的青年。第二个目的是确定大脑皮层厚度与焦虑的两个组成部分显着相关。结果表明，右前额叶皮层与焦虑唤醒有较强的关系，而背外侧前额叶皮层和左前额叶皮层被发现与焦虑唤醒和忧虑。我们还观察到杏仁核和海马体的体积差异之间的焦虑唤醒和焦虑忧虑。而焦虑唤醒，而不是忧虑，预测左杏仁核体积，焦虑忧虑，而不是唤醒，预测右海马体积。这些发现表明，在神经区域中存在差异和相似之处，这些区域有助于焦虑的独立方面。结果进行了讨论，从情感和发展认知神经科学以前的研究结果。
Neuroscientific and psychological research posits that there are two transdiagnostic facets of anxiety: anxious arousal and anxious apprehension. Though these two facets of anxiety are distinct, they are often subsumed into one domain (e.g., trait anxiety). The primary goal of the current study was to delineate the relationship between anxious arousal and cortical thickness versus the relationship between anxious apprehension and cortical thickness in a sample of typically functioning youth. The secondary aim was to determine where in the brain cortical thickness significantly correlated with both components of anxiety. Results indicated that the right anterior insula has a stronger relationship to anxious arousal, whereas the dorsolateral prefrontal cortex and left anterior insula were found to correlate with both anxious arousal and apprehension. We also observed volumetric differences in the amygdala and hippocampus between anxious arousal and anxious apprehension. Whereas anxious arousal, but not apprehension, predicted left amygdala volume, anxious apprehension, but not arousal, predicted right hippocampal volume. These findings demonstrated that there are both differences and similarities in the neural regions that contribute to independent facets of anxiety. Results are discussed in terms of previous findings from the affective and developmental cognitive neurosciences.