SKIN MANIFESTATIONS ASSOCIATED WITH TUMORS OF BRAIN
SKIN MANIFESTATIONS ASSOCIATED WITH TUMORS OF BRAIN
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DOI：
10.1111/j.1365-2133.1975.tb03148.x
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发表时间：
1975-01-01
影响因子：
10.3
通讯作者：
PETKOV, I
中科院分区：
文献类型：
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作者：
ANDREEV, VC;PETKOV, I
在4年的时间里，对77例脑肿瘤患者的皮肤表现进行了研究。在24例（31.2%）中观察到这些症状，分为三个主要组：瘙痒。13例患者主诉瘙痒。最具特征的是鼻孔瘙痒，在6名患者中观察到。它可以是非常严重的，是一个先进的肿瘤的迹象。在两个，白癜风同时出现脑肿瘤症状。其余患者在病程后期出现面部色素沉着，4例出现角化过度改变。两个有轻微的手掌和脚底角化过度。另外两个开发除了鱼鳞病样皮肤萎缩。与脑肿瘤相关的皮肤表现的可能发病机制进行了讨论。
In a 4‐year period seventy‐seven patients with tumours of the brain were investigated for skin manifestations. These were observed in twenty‐four (31.2%) and fall into three main groups:Pruritus. Thirteen patients complained of pruritus. Most characteristic is the pruritus of the nostrils, which was observed in six patients. It can be extremely severe and is a sign of an advanced tumour.Pigmentary disorderswere observed in seven patients. In two, vitiligo appeared simultaneously with the brain tumour symptoms. In the others, hyperpigmentation appeared on the face later in the course of the disease.Hyperkeratotic changeswere manifest in four patients. Two had a mild hyperkeratosis of the palms and soles. The other two developed in addition an ichthyosiform atrophy of the skin.The possible pathogenesis of the skin manifestations associated with brain tumours is discussed.