Association of MIF in serum and synovial fluid with severity of knee osteoarthritis
Association of MIF in serum and synovial fluid with severity of knee osteoarthritis
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DOI：
10.1016/j.clinbiochem.2012.03.012
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发表时间：
2012-07-01
影响因子：
2.8
通讯作者：
Hu, Chunhe
中科院分区：
文献类型：
--
作者：
Liu, Minghui;Hu, Chunhe
目的：近年来研究表明，炎症在骨关节炎（OA）的发生、发展中起重要作用。本研究旨在检测膝关节OA患者血清和滑液中巨噬细胞移动抑制因子（macrophage migration inhibitor factor，MIF）的水平，并分析其与OA严重程度的关系。Kellgren和Lawrence（KL）4级的膝关节OA患者与KL 2级和3级患者相比，血清和SF中的MIF水平显著升高。结论：膝关节OA患者血清及SF中MIF水平与OA的X线严重程度密切相关。(C)2012年加拿大临床化学家协会。爱思唯尔公司出版All rights reserved.
Objective: Recent evidences suggest that inflammation contributes to the development and progression of osteoarthritis (OA). This study aims to determine macrophage migration inhibitory factor (MIF) levels in serum and synovial fluid (SF) of patients with knee OA and to analyze the association of MIF levels with the radiographic severity of OA.Design and methods: 224 patients with knee OA and 186 healthy controls were enrolled in this study.Results: Higher levels of serum MIF were found in knee OA patients compared with healthy controls. Knee OA patients with Kellgren and Lawrence (KL) grade 4 showed significantly elevated MIF levels in serum and SF compared with those with KL grade 2 and 3. MIF levels in serum and SF of knee OA patients were significantly related to disease severity evaluated by KL grading criteria.Conclusion: MIF levels in serum and SF were closely related to the radiographic severity of OA. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.