CCR5del32 in perinatal HIV-1 infection.
CCR5del32 in perinatal HIV-1 infection.
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CCR5del32 在围产期 HIV-1 感染中的作用。
DOI：
10.1097/00042560-199712010-00003
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
King,MC
中科院分区：
文献类型：
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作者：
Rousseau,CM;Just,JJ;Abrams,EJ;Casabona,J;Stein,Z;King,MC
趋化因子受体CCR5是嗜巨噬细胞HIV-1(1-3)的辅助受体。编码CCR5的基因CCR5del32内32个碱基的缺失已被证明在缺乏野生型等位基因的情况下可以防止HIV-1感染T细胞。这种改变在高加索人群中出现的频率很低(4-6)。为了探讨CCR5del32基因在围产期HIV-1传播和疾病进展中的作用，对围产期接触感染和未感染的两组儿童进行了等位基因的检测。应用聚合酶链式反应(PCR)对144名来自纽约市的非裔美国儿童和73名来自西班牙巴塞罗那的高加索儿童进行了CCR5del32流行和潜在病例的检测。比较了患有和不患有CCR5del32的儿童的HIV-1传播；疾病的临床表现，包括脑病、机会性感染和2岁前死亡；生存率；疾病控制和预防中心(CDC)的分类；以及免疫抑制的程度。感染HIV-1的非裔美国人的等位基因频率(0.016)低于加泰罗尼亚儿童(0.041)。在这些队列中没有发现CCR5del32对HIV-1传播或疾病进展具有显性保护作用的证据。
CCR5, a chemokine receptor, serves as a coreceptor for macrophage-tropic HIV-1 (1-3). A 32-bp deletion within the gene encoding CCR5, CCR5del32, has been shown to prevent HIV-1 infection of T cells in the absence of a wild-type allele. This alteration is present in low frequency in Caucasian populations (4-6). To investigate the effect of CCR5del32 in perinatal HIV-1 transmission and disease progression, two cohorts of perinatally exposed infected and uninfected children were analyzed for the presence of the allele. Polymerase chain reaction (PCR) was used to identify CCR5del32 in prevalent and prospective cases among 144 African American children from New York City and 73 Caucasian children from Barcelona, Spain. HIV-1 transmission; clinical manifestations of disease, including encephalopathy, opportunistic infections, and death before 2 years of age; survival; Centers for Disease Control and Prevention (CDC) classification; and degree of immunosuppression were compared in children with and without CCR5del32. The allele frequency in HIV-1-infected African Americans (0.016) was lower than in Catalan children (0.041). No evidence for a dominant protective effect of CCR5del32 for HIV-1 transmission or disease progression was found in these cohorts.