Residential exposure to magnetic fields and acute lymphoblastic leukemia in children
Residential exposure to magnetic fields and acute lymphoblastic leukemia in children
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DOI：
10.1056/nejm199707033370101
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发表时间：
1997-07-03
影响因子：
158.5
通讯作者：
Tarone, RE
中科院分区：
文献类型：
--
作者：
Linet, MS;Hatch, EE;Tarone, RE
背景以前的研究发现儿童白血病与暴露于磁场的替代指标之间存在关联（电力线分类方案称为“电线编码”），但儿童白血病与60 Hz住宅磁场测量结果之间无显著性差异。在一项关于住宅暴露于附近输电线产生的磁场的研究中，15岁以下的儿童和620名对照者在儿童癌症组织登记。在受试者现在和以前的家中，数据收集者对受试者的健康状况不知情，在每个孩子的卧室测量磁场24小时，在其他三四个房间和前门外测量磁场30秒。一种计算机算法，根据附近电力线的距离和配置分配电线代码类别，目标的主要住所（416例病例组和416例对照组）和母亲怀孕期间家庭居住的受试者结果儿童ALL的发病风险与时间加权平均住宅磁场水平无关，根据先验标准分类。与暴露量小于0.065 mu T相比，暴露量为0.200 mu T或更高时ALL的比值比为1.24（95%置信区间，0.86 - 1.79）。在主要居住地为最高有线编码类别的儿童中，ALL的风险并没有增加（与最低类别相比，比值比为0.88; 95%置信区间为0.48至1.63）。此外，风险是没有显着相关的住宅磁场水平或电线代码的母亲居住在怀孕时的subjects.Conclusions我们的研究结果提供了很少的证据表明，生活在家中的特点是高测量时间加权平均磁场水平或最高的电线代码类别增加儿童ALL的风险。(C)1997年，马萨诸塞州医学会。
Background Previous studies found associations between childhood leukemia and surrogate indicators of exposure to magnetic fields (the power-line classification scheme known as ''wire coding''), but not between childhood leukemia and measurements of 60-Hz residential magnetic fields.Methods We enrolled 638 children with acute lymphoblastic leukemia (ALL) who were under 15 years of age and were registered with the Children's Cancer Group and 620 controls in a study of residential exposure to magnetic fields generated by nearby power lines. In the subjects' current and former homes, data collectors blinded to the subjects' health status measured magnetic fields for 24 hours in each child's bedroom and for 30 seconds in three or four other rooms and outside the front door. A computer algorithm assigned wire-code categories, based on the distance and configuration of nearby power lines, to the subjects' main residences (for 416 case patients and 416 controls) and to those where the family had lived during the mother's pregnancy with the subject (for 230 case patients and 230 controls).Results The risk of childhood ALL was not linked to summary time-weighted average residential magnetic-field levels, categorized according to a priori criteria. The odds ratio for ALL was 1.24 (95 percent confidence interval, 0.86 to 1.79) at exposures of 0.200 mu T or greater as compared with less than 0.065 mu T. The risk of ALL was not increased among children whose main residences were in the highest wire-code category (odds ratio as compared with the lowest category, 0.88; 95 percent confidence interval, 0.48 to 1.63). Furthermore, the risk was not significantly associated with either residential magnetic-field levels or the wire codes of the homes mothers resided in when pregnant with the subjects.Conclusions Our results provide little evidence that living in homes characterized by high measured time-weighted average magnetic-field levels or by the highest wire-code category increases the risk of ALL in children. (C) 1997, Massachusetts Medical Society.