COVID-19 in solid organ transplantation patients: A systematic review
COVID-19 in solid organ transplantation patients: A systematic review
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DOI：
10.6061/clinics/2020/e1983
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发表时间：
2020-01-01
期刊：
影响因子：
2.7
通讯作者：
D'Albuquerque, Luiz Carneiro
中科院分区：
文献类型：
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作者：
Nacif, Lucas Souto;Zanini, Leonardo Y.;D'Albuquerque, Luiz Carneiro
冠状病毒病 (COVID-19) 会迅速发展为严重急性呼吸系统综合症。本综述旨在整理实体器官移植 (SOT) 患者中 COVID-19 感染的现有数据。我们对感染严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的 SOT 患者进行了系统评价。 MEDLINE 和 PubMed 数据库通过电子方式搜索和更新，直至 2020 年 4 月 20 日。使用的 MeSH 术语是“COVID-19”和“移植”。SOT 患者中报告了 39 例 COVID-19 病例。移植后发生 SARS-CoV-2 感染的中位间隔为 4 年，病死率为 25.64%（10/39）。肝移植（LT）患者中有 16 例，移植后的中位间隔为 5 年。 LT 患者的死亡率为 37.5%（6/16），死亡发生在 LT 后 3 年以上。死亡的最年轻患者59岁；没有儿童死亡。肾移植 (KT) 患者中有 23 例被描述。移植后的中位间隔为 4 年，死亡率为 17.4% (4/23)。死亡的最年轻患者71岁。在所有移植患者中，60岁以上患者中，COVID-19的死亡率最高：LT，62.5% vs 12.5% (p=0.006)； KT 44.44% vs 0 (p=0.039)；和 SOT，52.94% vs 4.54% (p=0.001)。这项研究对腹部 SOT 接受者中的 COVID-19 进行了新颖的描述。此外，我们提醒医疗专业人员注意 60 岁以上患者的死亡风险较高。
Coronavirus disease (COVID-19) rapidly progresses to severe acute respiratory syndrome. This review aimed at collating available data on COVID-19 infection in solid organ transplantation (SOT) patients.We performed a systematic review of SOT patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The MEDLINE and PubMed databases were electronically searched and updated until April 20, 2020. The MeSH terms used were "COVID-19'' AND "Transplant.''Thirty-nine COVID-19 cases were reported among SOT patients. The median interval for developing SARS-CoV-2 infection was 4 years since transplantation, and the fatality rate was 25.64% (10/39). Sixteen cases were described in liver transplant (LT) patients, and the median interval since transplantation was 5 years. The fatality rate among LT patients was 37.5% (6/16), with death occurring more than 3 years after LT. The youngest patient who died was 59 years old; there were no deaths among children. Twenty-three cases were described in kidney transplant (KT) patients. The median interval since transplantation was 4 years, and the fatality rate was 17.4% (4/23). The youngest patient who died was 71 years old. Among all transplant patients, COVID-19 had the highest fatality rate in patients older than 60 years : LT, 62.5% vs 12.5% (p=0.006); KT 44.44% vs 0 (p=0.039); and SOT, 52.94% vs 4.54% (p=0.001).This study presents a novel description of COVID-19 in abdominal SOT recipients. Furthermore, we alert medical professionals to the higher fatality risk in patients older than 60 years.