Calciphylaxis: Comparison of radiologic imaging and histopathology
Calciphylaxis: Comparison of radiologic imaging and histopathology
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DOI：
10.1016/j.jaad.2017.01.040
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发表时间：
2017-08-01
影响因子：
13.8
通讯作者：
Wainwright, Sandra
中科院分区：
文献类型：
--
作者：
Halasz, Charles L.;Munger, David P.;Wainwright, Sandra
背景：目前诊断钙化反应的金标准是显示小口径动脉或小动脉钙化的皮肤活检标本。目的：本研究的目的是比较钙化血管的直径在皮肤活检标本和钙化患者的放射学图像。方法：我们对2009年至2016年在一家社区医院就诊的已知钙化反应患者进行了回顾性研究，这些患者的皮肤活检标本和放射学图像都是其常规护理的一部分。比较皮肤活检标本和放射影像的血管钙化情况。结果：确定了7例患者。3例平片见细至0.1 ~ 0.3 mm的小血管钙化；3例患者乳房x光检查为0.1 - 0.2 mm， 1例患者计算机断层扫描为0.1 - 0.2 mm，几乎与组织病理学检查一样精细。局限性：本研究为单中心研究，样本量有限。结论：当皮肤活检标本等待或无法获得时，放射影像学检查可以更快速地诊断钙化反应。
Background: The current gold standard for diagnosis of calciphylaxis is a skin biopsy specimen demonstrating calcification of small-caliber arteries or arterioles.Objective: The aim of this study is to compare diameters of calcified vessels seen in skin biopsy specimens and radiology images of patients with calciphylaxis.Methods: We conducted a retrospective study of patients with known calciphylaxis from 2009 to 2016 at a community hospital who had both skin biopsy specimens and radiology images taken as part of their routine care. Vascular calcification was compared in skin biopsy specimens and radiology images.Results: Seven patients were identified. Small-vessel calcification as fine as 0.1 to 0.3 mm was identified on plain films in 3 patients; 0.1 to 0.2 mm by mammography in 3 patients, and 0.1 to 0.2 mm by computed tomography imaging in 1 patient, nearly as fine a resolution as on histopathology.Limitations: This was a single-center study with limited sample size.Conclusion: Radiologic imaging might enable more rapid diagnosis of calciphylaxis when skin biopsy specimen is pending or not available.