Comparison of macular GCIPL and peripapillary RNFL deviation maps for detection of glaucomatous eye with localized RNFL defect
Comparison of macular GCIPL and peripapillary RNFL deviation maps for detection of glaucomatous eye with localized RNFL defect
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DOI：
10.1111/aos.12485
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发表时间：
2015-02-01
影响因子：
3.4
通讯作者：
Kim, Dong Myung
中科院分区：
文献类型：
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作者：
Kim, Mi Jeung;Park, Ki Ho;Kim, Dong Myung
目的：评价黄斑神经节细胞-内丛状层（GCIPL）厚度与乳头周围视网膜神经纤维层（pRNFL）厚度偏差图对无红RNFL摄影显示的局部RNFL缺陷的检测能力。方法：本前瞻性横断面研究纳入69例眼周前或眼周青光眼（平均偏差(MD) >-12dB）和局限性RNFL缺损的69只眼以及79例正常对照的79只眼。使用定制的Matlab程序计算黄斑GCIPL和pRNFL局部RNFL缺陷对应的Cirrus OCT偏差图上的异常超像素个数，并根据每个概率水平作为严重性指数表示。比较两种偏差图的受试者工作特征曲线（auroc）下面积。结果：GCIPL和pRNFL偏差图的auroc分别为0.910 ~ 0.931和0.934 ~ 0.950。但差异无统计学意义（p < 0.05）。无论何种标准，GCIPL偏差图的严重程度指数与pRNFL偏差图的严重程度指数之间均存在显著相关性（均p < 0.0001）。结论：黄斑GCIPL厚度偏差图与pRNFL厚度偏差图对局限性RNFL缺陷青光眼的诊断效果相当。
Purpose: To evaluate the ability of the deviation map of macular ganglion cell-inner plexiform layer (GCIPL) thickness compared with that of peripapillary retinal nerve fibre layer (pRNFL) thickness for detection of localized RNFL defects shown on red-free RNFL photography.Methods: This prospective cross-sectional study included 69 eyes of 69 subjects with preperimetric or perimetric glaucoma (mean deviation (MD) >-12dB) and localized RNFL defects along with 79 eyes of 79 normal control subjects. The number of abnormal superpixels on the both macular GCIPL and pRNFL deviation maps by Cirrus OCT corresponding to localized RNFL defects was calculated using a customized Matlab program and presented as severity indices according to each of the probability levels. The areas under the receiver operating characteristic curves (AUROCs) of the severity indices were compared between the two deviation maps.Results: According to three criteria and corresponding probability levels, the AUROCs of the GCIPL and pRNFL deviation maps ranged from 0.910 to 0.931 and 0.934 to 0.950, respectively. However, the differences were not statistically significant (all p > 0.05). Significant correlations were observed between the severity indices of the GCIPL deviation map and those of the pRNFL deviation map, regardless of the criteria (all p < 0.0001).Conclusions: In the detection of glaucomatous eyes with localized RNFL defects, the macular GCIPL thickness deviation map showed a level of diagnostic performance comparable to that of the pRNFL thickness deviation map.