Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence.
Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence.
复制标题
针对 GABA 能系统的草药失眠药物：精神药理学证据回顾
DOI：
10.2174/1570159x11666131227001243
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发表时间：
2014-05
影响因子：
5.3
通讯作者：
Zhang JJ
中科院分区：
文献类型：
--
作者：
Shi Y;Dong JW;Zhao JH;Tang LN;Zhang JJ
失眠是一种常见的睡眠障碍，在女性和老年人中普遍存在。目前治疗失眠的药物主要针对γ-氨基丁酸受体、褪黑素受体、组胺受体、食欲素和5-羟色胺受体。GABAA受体调节剂通常用于治疗失眠，但已知它们会影响睡眠维持，包括残留效应、耐受性和依赖性。为了发现在缓解失眠症状的同时避免副作用的新药，人们已经进行了大量的研究，重点是神经递质GABA和草药。传统中草药，如胡椒和酸枣仁。Spinosa，已被广泛报道可改善睡眠和其他精神障碍。这些草药在民间医学中已经应用多年，这些药物的提取物被用来研究它们的药理作用和机制。天然植物产品虽然有效且相对安全，但也有一些副作用，如甲基胡椒的肝脏毒性和皮肤反应。此外，没有足够的证据证明大多数传统草药的安全性。在这篇综述中，我们提供了关于各种天然植物产品的知识现状的概述，这些产品通常用于治疗失眠，以促进未来的研究。
Insomnia is a common sleep disorder which is prevalent in women and the elderly. Current insomnia drugs mainly target the γ-aminobutyric acid (GABA) receptor, melatonin receptor, histamine receptor, orexin, and serotonin receptor. GABAA receptor modulators are ordinarily used to manage insomnia, but they are known to affect sleep maintenance, including residual effects, tolerance, and dependence. In an effort to discover new drugs that relieve insomnia symptoms while avoiding side effects, numerous studies focusing on the neurotransmitter GABA and herbal medicines have been conducted. Traditional herbal medicines, such as Piper methysticum and the seed of Zizyphus jujuba Mill var. spinosa, have been widely reported to improve sleep and other mental disorders. These herbal medicines have been applied for many years in folk medicine, and extracts of these medicines have been used to study their pharmacological actions and mechanisms. Although effective and relatively safe, natural plant products have some side effects, such as hepatotoxicity and skin reactions effects of Piper methysticum. In addition, there are insufficient evidences to certify the safety of most traditional herbal medicine. In this review, we provide an overview of the current state of knowledge regarding a variety of natural plant products that are commonly used to treat insomnia to facilitate future studies.