Inhibitory gating of vibrissal inputs in the brainstem
Inhibitory gating of vibrissal inputs in the brainstem
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DOI：
10.1523/jneurosci.4627-07.2008
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发表时间：
2008-02-20
影响因子：
5.3
通讯作者：
Deschenes, Martin
中科院分区：
文献类型：
--
作者：
Furuta, Takahiro;Timofeeva, Elena;Deschenes, Martin
三叉神经感觉核团是啮齿类动物触须系统的第一个加工阶段。它们的特点是丘脑投射细胞的独立群体和丰富的亚核间连接网络，因此，通过每一条触须信息的上行通路传递到皮层的信息取决于脑干中发生的局部交易。在本研究中，我们研究了这些intersubnuclear连接的性质相结合的电解病变与电生理记录，逆行标记与原位杂交，顺行标记与免疫电镜。总之，这些不同的方法提供了确凿的证据表明，三叉神经主核接收抑制性GABA能投射从尾侧部的极间亚核，和兴奋性GABA能投射从尾侧亚核。这些结果提出了这样的可能性，即通过控制核间投射细胞的活动，投射到三叉神经脊束核的脑区可能会积极参与选择通过丘系通路传递的触须信息的类型。
Trigeminal sensory nuclei are the first processing stage in the vibrissal system of rodents. They feature separate populations of thalamic projecting cells and a rich network of intersubnuclear connections, so that what is conveyed to the cortex by each of the ascending pathways of vibrissal information depends on local transactions that occur in the brainstem. In the present study, we examined the nature of these intersubnuclear connections by combining electrolytic lesions with electrophysiological recordings, retrograde labeling with in situ hybridization, and anterograde labeling with immunoelectron microscopy. Together, these different approaches provide conclusive evidence that the principal trigeminal nucleus receives inhibitory GABAergic projections from the caudal sector of the interpolaris subnucleus, and excitatory glutamatergic projections from the caudalis subnucleus. These results raise the possibility that, by controlling the activity of intersubnuclear projecting cells, brain regions that project to the spinal trigeminal nuclei may take an active part in selecting the type of vibrissal information that is conveyed through the lemniscal pathway.