HIGH-LEVELS OF INTERFERON-ALPHA IN THE SERA OF CHILDREN WITH DENGUE VIRUS-INFECTION
HIGH-LEVELS OF INTERFERON-ALPHA IN THE SERA OF CHILDREN WITH DENGUE VIRUS-INFECTION
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DOI：
10.4269/ajtmh.1993.48.222
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发表时间：
1993-02-01
影响因子：
3.3
通讯作者：
ENNIS, FA
中科院分区：
文献类型：
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作者：
KURANE, I;INNIS, BL;ENNIS, FA
我们测量了因登革出血热（DHF）或登革热（DF）住院的泰国儿童血清中干扰素α (ifn α)的水平，以研究干扰素α在人类登革病毒感染中的作用。检测到ifn - α水平（大于或等于3u /ml）的患者百分比在DHF患者中（80%,P < 0.001）和DF患者中（60%,P < 0.001）高于泰国健康儿童（7%）。DHF患者和DF患者在发烧后最初几天的ifn - α水平高于健康的泰国儿童。DHF患者的ifn - α平均水平在退热前2天较高，在退热当天逐渐降低。有一部分DHF患者在退热后ifn - α水平升高。然而，DF患者的ifn - α水平在发烧消退后并不高。DHF 1级、2级和3级患儿的ifn - α水平无显著差异。在DHF患者中，高干扰素α产生者的T淋巴细胞被激活的程度高于低干扰素α产生者。这些结果表明，在DHF和DF的急性阶段，体内产生同样高水平的ifn - α，并且在一些DHF患者发烧消退后仍保持高水平的ifn - α，但在DF患者中没有。
We measured the levels of interferon alpha (IFNalpha) in the sera of Thai children hospitalized with dengue hemorrhagic fever (DHF) or dengue fever (DF) to examine the role of IFNalpha in dengue virus infections of humans. The percentage of patients who had detectable levels of IFNalpha (greater-than-or-equal-to 3 U/ml) was higher in patients with DHF (80%, P < 0.001) and in patients with DF (60%, P < 0.001) than in healthy Thai children (7%). The levels of IFNalpha were higher in patients with DHF and in patients with DF on the first few days after the onset of fever than in healthy Thai children. The average levels of IFNalpha in patients with DHF were high two days before defervescence, decreasing gradually until the day of defervescence. There was a subset of patients with DHF who had increasing levels of IFNalpha after defervescence. However, the levels of IFNalpha in patients with DF were not high after fever subsided. The levels of IFNalpha were not different among children with DHF grades 1, 2 and 3. Among patients with DHF, T lymphocytes were activated to a higher degree in high IFNalpha producers than in low IFNalpha producers. These results indicate that similarly high levels of IFNalpha are produced in vivo during the acute stages of DHF and DF, and that high levels of IFNalpha remain after fever subsides in some patients with DHF, but not in patients with DF.