The Bio-SANS instrument at the High Flux Isotope Reactor of Oak Ridge National Laboratory
The Bio-SANS instrument at the High Flux Isotope Reactor of Oak Ridge National Laboratory
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DOI：
10.1107/s1600576714011285
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发表时间：
2014-08-01
影响因子：
6.1
通讯作者：
Myles, Dean A.
中科院分区：
文献类型：
--
作者：
Heller, William T.;Urban, Volker S.;Myles, Dean A.
小角中子散射（SANS）是表征包括生物材料在内的复杂无序材料的有力工具。橡树岭国家实验室（ORNL）高通量同位素反应堆的Bio-SANS仪器是一种高通量低背景的SANS仪器，在SANS仪器中是独一无二的，致力于服务于结构生物学和生物材料社区的需求，作为开放访问的用户设施。本文介绍了Bio-SANS的技术指标和性能。还介绍了为满足仪器用户程序的需求而开发的示例环境。此外，还描述了生物氘化实验室为Bio-SANS和ORNL其他中子散射仪器的用户提供的同位素标记和样品制备能力。最后，对使用Bio-SANS进行的研究进行了简要的调查，这表明了该仪器的用户群体所从事的研究的广度。(C) 2014年国际晶体学联合会
Small-angle neutron scattering (SANS) is a powerful tool for characterizing complex disordered materials, including biological materials. The Bio-SANS instrument of the High Flux Isotope Reactor of Oak Ridge National Laboratory (ORNL) is a high-flux low-background SANS instrument that is, uniquely among SANS instruments, dedicated to serving the needs of the structural biology and biomaterials communities as an open-access user facility. Here, the technical specifications and performance of the Bio-SANS are presented. Sample environments developed to address the needs of the user program of the instrument are also presented. Further, the isotopic labeling and sample preparation capabilities available in the Bio-Deuteration Laboratory for users of the Bio-SANS and other neutron scattering instruments at ORNL are described. Finally, a brief survey of research performed using the Bio-SANS is presented, which demonstrates the breadth of the research that the instrument's user community engages in. (C) 2014 International Union of Crystallography