Traffic-Related Air Pollution and Parkinson's Disease in Denmark: A Case-Control Study.
Traffic-Related Air Pollution and Parkinson's Disease in Denmark: A Case-Control Study.
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DOI：
10.1289/ehp.1409313
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发表时间：
2016-03
影响因子：
10.4
通讯作者：
Raaschou-Nielsen O
中科院分区：
文献类型：
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作者：
Ritz B;Lee PC;Hansen J;Lassen CF;Ketzel M;Sørensen M;Raaschou-Nielsen O
目前对空气污染物对神经退行性疾病的不利影响知之甚少，尽管最近的研究将颗粒暴露与帕金森病和阿尔茨海默病相关的大脑病理联系起来。在本研究中，我们调查了长期暴露于交通相关的空气污染和帕金森病。在一项病例对照研究中，我们评估了1996-2009年从丹麦医院登记处确定并诊断的1，696名帕金森病（PD）患者和1，800名按性别和出生年份匹配的人群对照，我们评估了长期交通相关空气污染物暴露（以二氧化氮为代表，NO2）的扩散模型，使用1971年至诊断日期或第一次主要症状日期的居住地址作为病例，并使用相应的索引日期作为其匹配的对照。采用逻辑回归估计比值比（OR）和95%置信区间（CI），调整匹配因素和潜在混杂因素。我们发现来自交通源的环境空气污染与PD风险相关，在模拟的NO2中，每四分位数范围增加（2.97 μg/m3），风险增加9%（95% CI：3，16.0%）。对于在省会城市居住≥ 20年的参与者，OR（OR = 1.21; 95%CI：1.11，1.31）大于省级城镇（OR = 1.10; 95%CI：0.97，1.26），而农村居民之间没有相关性。我们的研究结果引起了人们对交通和其他来源的空气污染对PD风险的潜在影响的担忧，特别是在高暴露或暴露增加的人群中。[10]李PC，汉森J，李李B，冯克·拉森C，Ketzel M，Sørensen M，Raaschou-Nielsen O. 2016.丹麦与帕金森病相关的空气污染：一项病例对照研究环境健康展望124：351-356; http：dx.doi.org/10.1289/ehp.1409313
Very little is currently known about air pollutants’ adverse effects on neurodegenerative diseases even though recent studies have linked particulate exposures to brain pathologies associated with Parkinson’s and Alzheimer’s disease. In the present study, we investigated long-term exposure to traffic-related air pollution and Parkinson’s disease. In a case–control study of 1,696 Parkinson’s disease (PD) patients identified from Danish hospital registries and diagnosed 1996–2009 and 1,800 population controls matched by sex and year of birth, we assessed long-term traffic-related air pollutant exposures (represented by nitrogen dioxide; NO2) from a dispersion model, using residential addresses from 1971 to the date of diagnosis or first cardinal symptom for cases and the corresponding index date for their matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated with logistic regression, adjusting for matching factors and potential confounders. We found ambient air pollution from traffic sources to be associated with risk of PD, with a 9% higher risk (95% CI: 3, 16.0%) per interquartile range increase (2.97 μg/m3) in modeled NO2. For participants living for ≥ 20 years in the capital city, ORs were larger (OR = 1.21; 95% CI: 1.11, 1.31) than in provincial towns (OR = 1.10; 95% CI: 0.97, 1.26), whereas there was no association among rural residents. Our findings raise concerns about potential effects of air pollution from traffic and other sources on the risk of PD, particularly in populations with high or increasing exposures. Ritz B, Lee PC, Hansen J, Funch Lassen C, Ketzel M, Sørensen M, Raaschou-Nielsen O. 2016. Traffic-related air pollution and Parkinson’s disease in Denmark: a case–control study. Environ Health Perspect 124:351–356; http://dx.doi.org/10.1289/ehp.1409313