Association of sLR11 gene polymorphism with T2DM and carotid atherosclerosis.
Association of sLR11 gene polymorphism with T2DM and carotid atherosclerosis.
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DOI：
10.3233/thc-171040
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发表时间：
2018-06
期刊：
影响因子：
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通讯作者：
F. Du;Dan Li;Lianshan Piao;Kang-juan Yang
中科院分区：
文献类型：
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作者：
F. Du;Dan Li;Lianshan Piao;Kang-juan Yang
目的探讨延边地区朝鲜族和汉族人群中可溶性低密度脂蛋白受体11(SLR11)基因单核苷酸多态性(SNPs)与2型糖尿病(T2 DM)和颈动脉粥样硬化(CAS)的关系。方法5 30例T2 DM患者按颈动脉内中膜厚度分为两组：颈动脉内膜中层厚度(⩾)1.0 mm伴斑块的T2 DM组2 5 6例，颈动脉IMT1.0 mm伴斑块的T2 DM组2 74例。对显性和隐性模式进行了分析，但三组间的基因频率差异无统计学意义(P>；0.05)。三组朝鲜族和汉族人群的基因频率分布差异均无统计学意义(P>；0.05)。2.与临床指标的相关性分析：CAS组TT、AT患者的低密度脂蛋白-C水平显著高于AA组(P>；0.05)，为遗传优势模式。结论本研究首次确定T因子sLR11基因rs3824968多态可能通过调节低密度脂蛋白胆固醇浓度增加T2 DM患者发生CAS的风险，表现为遗传优势模式。
OBJECTIVE To investigate the association of single nucleotide polymorphisms (SNPs) of soluble low-density lipoprotein receptor 11 (sLR11) genes with type-2 diabetes mellitus (T2DM) and carotid atherosclerosis (CAS) in Korean and Han nationalities in the Yanbian area. METHODS 530 T2DM patients were divided into two groups according to the intima-media thickness (IMT) of the carotid artery: CAS group (n= 256, T2DM patients with carotid artery IMT ⩾ 1.0 mm and plaque) and non-CAS group (NCAS group, n= 274, T2DM patients with carotid IMT 0.05). The dominant and recessive modes were analyzed, but the difference in genotype frequency among these three groups was not statistically significant (P> 0.05). Differences in genotype frequency distribution between Korean and Han populations in all three groups were not statistically significant (P> 0.05). 2. Correlation analysis with clinical indicators: LDL-C levels in TT and AT patients in the CAS group were significantly higher than those in AA patients (P> 0.05), representing the dominant mode of inheritance.. CONCLUSION This study is the first to determine that the sLR11 gene rs3824968 polymorphic of factor T may increase the risk of CAS in T2DM patients by regulating the concentration of LDL-C, showing the dominant mode of inheritance.