Prenatal and early life exposure to traffic pollution and cardiometabolic health in childhood.
Prenatal and early life exposure to traffic pollution and cardiometabolic health in childhood.
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DOI：
10.1111/ijpo.12106
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发表时间：
2017-02
影响因子：
3.8
通讯作者：
Oken E
中科院分区：
文献类型：
--
作者：
Fleisch AF;Luttmann-Gibson H;Perng W;Rifas-Shiman SL;Coull BA;Kloog I;Koutrakis P;Schwartz JD;Zanobetti A;Mantzoros CS;Gillman MW;Gold DR;Oken E
产前暴露于交通污染与婴儿体重增加更快有关，但对儿童后期心脏代谢健康的影响尚不清楚。在波士顿地区Viva项目的1418名儿童中，我们评估了儿童早期（中位年龄3.3岁）和中期（中位年龄7.7岁）心脏代谢健康的人体测量学和生化参数。我们使用时空模型来估计产前和生命早期居住PM2.5和黑碳暴露以及交通密度和道路接近度。我们进行了线性回归分析，调整了社会人口统计数据，母亲在分娩时住在主要道路附近的儿童在儿童早期和中期有较高的不良心脏代谢风险标记。例如，母亲居住在距离主干道50米以下的儿童的总脂肪量比母亲居住在距离主干道200米以上的儿童的总脂肪量高2.1kg （95%CI: 0.8, 3.5）。黑碳暴露和交通密度通常与心脏代谢参数无关，而前一年的PM2.5暴露与改善的心脏代谢状况相关，这是自相矛盾的。母亲在分娩时住在主要道路附近的婴儿可能会有心脏代谢健康不良的风险。
Prenatal exposure to traffic pollution has been associated with faster infant weight gain, but implications for cardiometabolic health in later childhood are unknown. Among 1,418 children in Project Viva, a Boston-area pre-birth cohort, we assessed anthropometric and biochemical parameters of cardiometabolic health in early (median age 3.3 years) and mid- (median age 7.7 years) childhood. We used spatiotemporal models to estimate prenatal and early life residential PM2.5 and black carbon exposure as well as traffic density and roadway proximity. We performed linear regression analyses adjusted for sociodemographics Children whose mothers lived close to a major roadway at the time of delivery had higher markers of adverse cardiometabolic risk in early and mid-childhood. For example, total fat mass was 2.1kg (95%CI: 0.8, 3.5) higher in mid-childhood for children of mothers who lived < 50 m vs. ≥ 200m from a major roadway. Black carbon exposure and traffic density were generally not associated with cardiometabolic parameters, and PM2.5 exposure during the year prior was paradoxically associated with improved cardiometabolic profile Infants whose mothers lived close to a major roadway at the time of delivery may be at later risk for adverse cardiometabolic health.