Coherent Activation of DNA Tweezers: A "SET-RESET" Logic System

Coherent Activation of DNA Tweezers: A "SET-RESET" Logic System
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DOI:
10.1002/anie.200805819
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发表时间:
2009-01-01
影响因子:
16.6
通讯作者:
Willner, Itamar
Willner, Itamar
中科院分区:
化学1区
文献类型:
--
作者:
Elbaz, Johann;Moshe, Michal;Willner, Itamar

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芝麻开门:适体-底物复合物激活两个镊子的连贯操作,充当“设置-重置”逻辑系统。当由腺苷单磷酸 (AMP) 和腺苷脱氨酶 (AD) 触发时,每个镊子在荧光打开状态和关闭淬灭状态(Q=淬灭剂,F=荧光团)之间循环。
Open sesame: Aptamer–substrate complexes activate the coherent operation of two tweezers that act as a “SET–RESET” logic system. Each tweezer cycles between a fluorescent open state and a closed quenched state (Q=quencher, F=fluorophore) when triggered by adenosine monophosphate (AMP) and adenosine deaminase (AD).