The oviduct and ovarian cancer: causality, clinical implications, and "targeted prevention".
The oviduct and ovarian cancer: causality, clinical implications, and "targeted prevention".
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卵巢癌和卵巢癌：因果关系，临床意义和“靶向预防”。
DOI：
10.1097/grf.0b013e31824b1725
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发表时间：
2012-03
影响因子：
1.5
通讯作者：
Xian W
中科院分区：
文献类型：
--
作者：
Crum CP;McKeon FD;Xian W
盆腔浆液性癌(卵巢癌)的新起源已被提出在远端输卵管。这具有重要的意义，包括在高危女性中及早发现，以及依靠血清学测试来检测一种始于如此接近腹膜表面的疾病是否明智。随着最近在输卵管粘膜中发现的癌前基因功能紊乱，靶向预防的概念正在出现，通过阻断部分致癌途径将预防癌症。这种检测早期恶性肿瘤的替代方法是寻求预防这种致命疾病的新范式。
A novel origin for pelvic serous cancer (ovarian cancer) has been proposed in the distal oviduct. This has important implications, including both early detection in high-risk women and wisdom of relying on serological tests to detect a disease that begins so close to the peritoneal surfaces. With the recent discovery of -premalignant disturbances in gene function in the tubal mucosa the concept of targeted prevention is emerging whereby the interruption of a portion of the carcinogenic pathway will prevent cancer. This alternative to detecting early malignancy is a new paradigm in the quest to prevent this deadly disease.