Ventricular assist devices for children
Ventricular assist devices for children
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DOI：
10.1016/j.ppedcard.2005.11.005
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发表时间：
2006-03-01
影响因子：
0.9
通讯作者：
Duncan, Brian W.
中科院分区：
文献类型：
--
作者：
Baldwin, J. Timothy;Duncan, Brian W.
婴儿和儿童可能会经历如此严重的心力衰竭，以至于需要循环支持作为恢复、移植或其他手术干预的桥梁。虽然年龄较大的儿童可以通过专为成人设计的设备进行支持，但从历史上看，儿科循环支持的选择仅限于体外膜氧合器(ECMO)、基于离心泵的短期心室辅助装置(VAD)和副心脏VAD。然而，这些装置在儿科人群中存在发生不良事件的巨大风险。为了满足为最年轻的儿科患者改进循环支持设备的需求，正在开发专门针对这一弱势群体的新设备。其中包括植入式旋转式血泵、紧凑型心肺辅助系统以及用于急慢性支持的体外搏动和旋转泵。预计不久将有几种设备可用于临床评估。这些设备有望为儿科循环支持所特有的挑战提供解决方案，例如预计将有越来越多的失败单心室患者接受过Fontan手术。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
Infants and children may experience such severe heart failure that circulatory support is required as a bridge to recovery, transplantation, or until other surgical intervention can be performed. While older children may be supported by devices designed for use in adults, historically, options for pediatric circulatory support have been limited to extracorporeal membrane oxygenators (ECMO), short-term centrifugal pump-based ventricular assist devices (VADs), and paracorporeal VADs. However, these devices present substantial risk for adverse events in the pediatric population. To address the need for improved circulatory support devices for the youngest pediatric patients, new devices specifically targeted to this vulnerable population are being developed. These include implantable rotary blood pumps, compact cardiopulmonary assist systems, and extracorporeal pulsatile and rotary pumps for acute and chronic support. Several devices are expected to be available for clinical evaluation soon. These devices will hopefully provide solutions for challenges that are unique to pediatric circulatory support, such as the anticipated growing population of failing single ventricle patients who have previously undergone a Fontan procedure. (C) 2005 Elsevier Ireland Ltd. All rights reserved.