Motivation, Perception, and Chance Converge to Make a Binary Decision.
Motivation, Perception, and Chance Converge to Make a Binary Decision.
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动机、感知和机会汇聚在一起做出二元决定。
DOI：
10.1016/j.neuron.2018.06.014
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发表时间：
2018
期刊：
影响因子：
16.2
通讯作者：
Crickmore,MichaelA
中科院分区：
文献类型：
--
作者：
Zhang,StephenX;Miner,LaurenE;Boutros,ChristineL;Rogulja,Dragana;Crickmore,MichaelA
我们揭示了一个中央的作用，机会神经元事件的决定，一个男性飞到法院，这可以被建模为一个抛硬币的几率设置的动机状态。这个决定是由雌性用雄性含有信息素受体的前腿轻拍引起的。每一次敲击都会引起对P1求偶命令神经元的竞争性兴奋和抑制。一个刺激性的多巴胺信号使P1对抑制作用不敏感，增加了成功启动求爱的轻拍比例。一旦求爱开始，同样的多巴胺音调加强P1的反复兴奋，维持高度积极的雄性求爱数分钟，并对终止进行缓冲。P1内的受体多样性创造了单独的通道，用于调节倾向，以启动和维持向适当目标的求爱。这些发现建立了一个强大的无脊椎动物系统的线索触发的二元决策，并表明，噪音可以利用激励系统，使行为的可扩展性和灵活性。
We reveal a central role for chance neuronal events in the decision of a male fly to court, which can be modeled as a coin flip with odds set by motivational state. The decision is prompted by a tap of a female with the male's pheromone-receptor-containing foreleg. Each tap evokes competing excitation and inhibition onto P1 courtship command neurons. A motivating dopamine signal desensitizes P1 to the inhibition, increasing the fraction of taps that successfully initiate courtship. Once courtship has begun, the same dopamine tone potentiates recurrent excitation of P1, maintaining the courtship of highly motivated males for minutes and buffering against termination. Receptor diversity within P1 creates separate channels for tuning the propensities to initiate and sustain courtship toward appropriate targets. These findings establish a powerful invertebrate system for cue-triggered binary decisions and demonstrate that noise can be exploited by motivational systems to make behaviors scalable and flexible.