Conditioning method determines patterns of c-fos expression following novel taste-illness pairing
Conditioning method determines patterns of c-fos expression following novel taste-illness pairing
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DOI：
10.1016/j.bbr.2005.12.006
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发表时间：
2006-04-25
影响因子：
2.7
通讯作者：
Bernstein, IL
中科院分区：
文献类型：
--
作者：
Wilkins, EE;Bernstein, IL
条件性味觉厌恶（CTA）可以通过将大鼠通过瓶子或通过口内（IO）输注暴露于新味道CS来建立。损伤研究表明，这两种方法在参与脑回路方面存在差异，因为兴奋性毒性杏仁核损伤对瓶条件CTA没有影响，但消除了使用IO输注产生的CTA。Fos样免疫反应（FLI）被用来比较使用瓶和IO方法配对CS味觉和US药物后的脑激活模式。使用瓶方法的调节大鼠与FLI在整个假定的CTA回路（杏仁核的基底外侧和中央核、岛叶皮质和孤束核）中的广泛升高相关。相比之下，IO条件反射只在杏仁核的中央核中激活。这支持了厌恶处理的差异作为条件反射方法的函数的建议，并且可以解释由于参与较少分布的神经网络而对IO条件CTA的杏仁核的更大依赖。(C)2006 Elsevier B.V.保留所有权利。
Conditioned taste aversions (CTAs) can be established by exposing rats to a novel taste CS through a bottle or through intra-oral (IO) infusion. Lesion studies suggest differences between the two methods in their engagement of brain circuits, as excitotoxic amygdala lesions have no effect on bottle-conditioned CTAs, but eliminate CTAs produced using IO infusion. Fos-like immunoreactivity (FLI) was used to compare patterns of brain activation after pairing CS taste and US drug using bottle and IO methods. Conditioning rats using the bottle method was associated with widespread elevations in FLI throughout the putative CTA circuit (basolateral and central nuclei of amygdala, insular cortex and nucleus of the solitary tract). In contrast, IO conditioning led to activation only in the central nucleus of amygdala. This supports the suggestion of differences in aversion processing as a function of conditioning method and may explain the greater reliance on amygdala of IO-conditioned CTAs due to engagement of a less distributed neural network. (C) 2006 Elsevier B.V. All rights reserved.