Estrogens receptors and oxidative damage in the liver
Estrogens receptors and oxidative damage in the liver
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DOI：
10.1016/s0303-7207(02)00100-4
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发表时间：
2002-07-31
影响因子：
4.1
通讯作者：
Villa, E
中科院分区：
文献类型：
--
作者：
Farinati, F;Cardin, R;Villa, E
有相当多的证据表明，ROS通过直接和间接机制在慢性肝损伤和癌症的发生中起到致病作用。雌激素通过氧化还原循环产生氧自由基，影响细胞增殖，在肝脏中也是如此。我们目前正在评估雌激素受体表达、受体类型、氧化DNA损伤和c-myc在慢性肝病中的可能关系。丙型肝炎或乙肝病毒相关性慢性肝病患者的DNA加合物、c-myc mRNA和变异雌激素受体的数据表明，变异肝雌激素受体阳性者表现为更高的基因组氧化损伤，这反映在8-OHdG水平上。我们还观察到，慢性肝炎和肝硬变患者，当雌激素受体变异体阳性时，c-myc m-RNA表达较高，据报道，这一因素与基因组不稳定性增加、细胞增殖增强和癌变有关。我们自己和其他作者的数据为雌激素的病理生理学、肝损伤和肝癌提供了新的线索。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
There is considerable evidence that reactive oxygen species (ROS) have a causative role in chronic hepatic injury and cancer development via direct and indirect mechanisms. Estrogens produce free oxygen radicals through redox cycling and affect cell proliferation, also in the liver. We are presently involved in evaluating the possible relationship between estrogens receptor expression, type of receptor, oxidative DNA damage and c-myc in chronic liver disease. The data on DNA adducts, c-myc mRNA and variant estrogen receptor in patients with HCV- or HBV-related chronic liver disease are suggesting that those positive for variant liver estrogen receptor present higher genomic oxidative damage, as reflected in 8-OHdG levels. We are also observing that patients with chronic hepatitis and cirrhosis, when positive for variant estrogen receptor, present higher c-myc m-RNA expression, a factor reportedly associated with increased genomic instability, augmented cytoproliferation and carcinogenesis. Our own and other author's data are shedding new light on estrogen pathophysiology, liver damage and hepatic cancer. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.