RISK-FACTORS FOR DEVELOPMENT OF RHEGMATOGENOUS RETINAL-DETACHMENT IN PATIENTS WITH CYTOMEGALOVIRUS RETINITIS
RISK-FACTORS FOR DEVELOPMENT OF RHEGMATOGENOUS RETINAL-DETACHMENT IN PATIENTS WITH CYTOMEGALOVIRUS RETINITIS
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DOI：
10.1016/s0002-9394(14)73471-3
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发表时间：
1993-12-15
影响因子：
4.2
通讯作者：
MUNGUIA, D
中科院分区：
文献类型：
--
作者：
FREEMAN, WR;FRIEDBERG, DN;MUNGUIA, D
我们研究了 259 名患者，以确定巨细胞病毒性视网膜炎患者发生视网膜脱离的时间依赖性风险和危险因素。六个月和一年的视网膜脱离率（通过眼睛）分别为 11% 和 24%。发现后极部以外视网膜表面受累的增加和视网膜炎活动的存在是最能预测视网膜脱离的两个协变量。周边受累超过 25% 的眼睛发生脱离的风险是受累 10% 的眼睛的五倍。如果存在视网膜炎活动性且超过 25% 的外周血管（主要血管弓外部）受累，则风险增加至 24 倍。对侧眼睛存在视网膜脱离并不是独立的危险因素。这些观察结果应有助于设计旨在预防视网膜脱离的预防性试验，还应有助于眼科医生为巨细胞病毒视网膜炎患者提供咨询。
We studied 259 patients to determine the time-dependent risk and risk factors for the development of retinal detachment in patients with cytomegalovirus retinitis. The six-month and one-year retinal detachment rates (by eye) were 11% and 24%, respectively. Increasing retinal surface involvement outside of the posterior pole and the presence of retinitis activity were found to be the two covariates that best predicted retinal detachment. Eyes with peripheral involvement greater than 25% had a fivefold risk for detachment, compared to eyes with 10% involvement. If there was retinitis activity and more than 25% peripheral (external to major vascular arcades) involvement, the risk increased to 24-fold. The presence of a fellow eye with retinal detachment was not an independent risk factor. These observations should help in the design of a prophylactic trial intended to prevent retinal detachment and should also help ophthalmologists counsel patients with cytomegalovirus retinitis.