Vimentin Suppresses Inflammation and Tumorigenesis in the Mouse Intestine.
Vimentin Suppresses Inflammation and Tumorigenesis in the Mouse Intestine.
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DOI：
10.3389/fcell.2022.862237
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发表时间：
2022
影响因子：
5.5
通讯作者：
Eriksson JE
中科院分区：
文献类型：
--
作者：
Wang L;Mohanasundaram P;Lindström M;Asghar MN;Sultana G;Misiorek JO;Jiu Y;Chen H;Chen Z;Toivola DM;Cheng F;Eriksson JE
Vimentin has been implicated in wound healing, inflammation, and cancer, but its functional contribution to intestinal diseases is poorly understood. To study how vimentin is involved during tissue injury and repair of simple epithelium, we induced colonic epithelial cell damage in the vimentin null (Vim−/−) mouse model. Vim−/− mice challenged with dextran sodium sulfate (DSS) had worse colitis manifestations than wild-type (WT) mice. Vim−/− colons also produced more reactive oxygen and nitrogen species, possibly contributing to the pathogenesis of gut inflammation and tumorigenesis than in WT mice. We subsequently describe that CD11b+ macrophages served as the mainly cellular source of reactive oxygen species (ROS) production via vimentin-ROS-pSTAT3–interleukin-6 inflammatory pathways. Further, we demonstrated that Vim−/− mice did not develop colitis-associated cancer model upon DSS treatment spontaneously but increased tumor numbers and size in the distal colon in the azoxymethane/DSS model comparing with WT mice. Thus, vimentin has a crucial role in protection from colitis induction and tumorigenesis of the colon.
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影响因子：
7.4
作者：
Kielland, Anders;Blom, Thomas;Carlsen, Harald
通讯作者：
Carlsen, Harald
影响因子：
5.4
作者：
Barberis, Laura;Pasquali, Christian;Hirsch, Emilio
通讯作者：
Hirsch, Emilio
影响因子：
4.6
作者：
Moisan, E.;Chiasson, S.;Girard, D.
通讯作者：
Girard, D.
影响因子：
4.9
作者：
Asghar, M. Nadeem;Emani, Rohini;Toivola, Diana M.
通讯作者：
Toivola, Diana M.
影响因子：
7.3
作者：
McGrath, J. C.;Drummond, G. B.;Wainwright, C. L.
通讯作者：
Wainwright, C. L.