The promise of copper ionophores as antimicrobials.
The promise of copper ionophores as antimicrobials.
复制标题
铜离子载体作为抗菌剂的前景。
DOI：
10.1016/j.mib.2023.102355
复制
发表时间：
2023
影响因子：
5.4
通讯作者：
Johnson,MichaelDL
中科院分区：
文献类型：
--
作者：
O'Brien,Henrik;Davoodian,Talish;Johnson,MichaelDL
抗药性微生物导致的死亡是一个重大的世界性健康问题。不幸的是，由于微生物的适应而产生耐药性，一些抗生素在使用早期就被取消了，更糟糕的是，甚至在开处方之前就检测到了耐药性。自古以来，铜对宿主-病原体界面上的微生物的毒性为对抗抗菌素耐药性提供了一种迷人的武器。在这里，我们简要回顾为什么铜如此有效，与铜一起工作的药物是如何有效的抗菌剂，以及这样的化合物如何重振对抗菌剂开发的投资。
Antibiotic-resistant microbe-mediated deaths are a major worldwide health issue. Unfortunately, due to microbial adaptation to develop resistance, some antibiotics are nullified early in their usage, and worse, resistance is detected before they can even be prescribed. Copper’s toxicity since antiquity against microbes at the host–pathogen interface offers a fascinating weapon to fight antimicrobial resistance. Here, we briefly review why copper is so effective, how drugs that work with copper are effective antimicrobials, and how compounds such as these could reinvigorate investment in antimicrobial development.