Complexity in interpretation of embryonic epithelial-mesenchymal transition in response to transforming growth factor-β signaling
Complexity in interpretation of embryonic epithelial-mesenchymal transition in response to transforming growth factor-β signaling
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DOI：
10.1159/000101314
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发表时间：
2007-01-01
影响因子：
2.7
通讯作者：
Nawshad, Ali
中科院分区：
文献类型：
--
作者：
Ahmed, Shaheen;Nawshad, Ali
上皮间质转化（EMT）是一个高度保守的和基本的过程，控制发育中的形态发生，也可能有助于癌症转移。转化生长因子（TGF-β）是多种发育和肿瘤系统中EMT的有效诱导剂。TGF-β信号转导通路的分析现在被认为是生物学的一个至关重要的领域，因为在胚胎发育中这些通路中存在许多缺陷。TGF-β信号转导网络的复杂性是压倒性的，这是由于除了有助于细胞信号传导的细胞动力学和酶学之外，它们还涉及大量相互作用的成分、复杂的前馈、反馈和串扰电路机制。由于这种复杂性，表面上简单但非常重要的问题仍然没有答案，即上皮细胞如何响应这种TGF-β信号？系统生物学和细胞动力学在细胞功能中起着至关重要的作用;遗漏这样一个关键的贡献者可能会导致对胚胎EMT的不准确理解。在这篇综述中，我们确定并解释了为什么某些条件需要考虑在体内TGF-β信号的真实代表，以更好地了解控制，但微妙的胚胎EMT机制。版权所有（c）2007 S. Karger AG，巴塞尔。
Epithelial-mesenchymal transition (EMT) is a highly conserved and fundamental process that governs morphogenesis in development and may also contribute to cancer metastasis. Transforming growth factor (TGF-beta) is a potent inducer of EMT in various developmental and tumor systems. The analysis of TGF-beta signal transduction pathways is now considered a critically important area of biology, since many defects occur in these pathways in embryonic development. The complexity of TGF-beta signal transduction networks is overwhelming due to the large numbers of interacting constituents, complicated feedforward, feedback and crosstalk circuitry mechanisms that they involve in addition to the cellular kinetics and enzymatics that contribute to cell signaling. As a result of this complexity, apparently simple but highly important questions remain unanswered, that is, how do epithelial cells respond to such TGF-beta signals? System biology and cellular kinetics play a crucial role in cellular function; omissions of such a critical contributor may lead to inaccurate understanding of embryonic EMT. In this review, we identify and explain why certain conditions need to be considered for a true representation of TGF-beta signaling in vivo to better understand the controlled, yet delicate mechanism of embryonic EMT. Copyright (c) 2007 S. Karger AG, Basel.