The association between vasectomy and prostate cancer:: a systematic review of the literature
The association between vasectomy and prostate cancer:: a systematic review of the literature
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DOI：
10.1016/s0015-0282(98)00142-3
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发表时间：
1998-08-01
影响因子：
6.7
通讯作者：
Gómez-López, LI
中科院分区：
文献类型：
--
作者：
Bernal-Delgado, E;Latour-Pérez, J;Gómez-López, LI
目的：为了评估输精管结扎术和前列腺癌之间可能存在的关联，设计：系统回顾文献。患者：14个原始研究发表于1985年1月至1996年12月，讨论了输精管结扎术和前列腺癌之间的关联。主要结果测量：使用荟萃分析（DerSimonian和Laird方法）估计关联的强度。结果：共检索到14篇原始文献，其中队列研究5篇，病例对照研究9篇。相对风险范围为0.44（95%置信区间[CI] = 0.1-4.0）至6.70（95% CI = 2.1-21.6）。总体相对风险（DerSimonian和Laird估计）为1.23（95% CI = 1.01-1.49）。敏感性分析表明，这项措施是非常敏感的研究基础，所使用的设计类型，和偏倚的可能性。此外，漏斗图显示可能存在发表偏倚。结论：输精管结扎术和前列腺癌之间没有因果关系。接受输精管结扎术的人患前列腺癌的风险并不高。（Fertil Steril（R）1998;70：191-200.（C）1998年由美国生殖医学学会出版。
Objective: To evaluate the possible association between vasectomy and prostate cancer.Design: Systematic review of the literature.Patient(s): Fourteen original studies published between January 1985 and December 1996 that addressed the association between vasectomy and prostate cancer.Main Outcome Measure(s): The strength of the association was estimated with the use of a meta-analysis (DerSimonian and Laird method). A sensitivity analysis was conducted to assess the impact of different sources of heterogeneity.Result(s): Fourteen original papers were reviewed (5 cohort and 9 case-control studies). Relative risks ranged between 0.44 (95% confidence interval [CI] = 0.1-4.0) and 6.70 (95% CI = 2.1-21.6). The overall relative risk (DerSimonian and Laird estimate) was 1.23 (95% CI = 1.01-1.49). The sensitivity analysis showed that this measure was very sensitive to the study base, the type of design used, and the possibility of bias. Further, the funnel plot demonstrated the probable existence of publication bias.Conclusion(s): No causal association was found between vasectomy and prostate cancer. Individuals who have undergone vasectomy are not at high risk for the development of prostate cancer. (Fertil Steril(R) 1998;70:191-200. (C)1998 by American Society for Reproductive Medicine.).