Positron emission tomography image-guided drug delivery: current status and future perspectives.
Positron emission tomography image-guided drug delivery: current status and future perspectives.
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DOI：
10.1021/mp500173s
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发表时间：
2014-11-03
影响因子：
4.9
通讯作者：
Cai W
中科院分区：
文献类型：
--
作者：
Chakravarty R;Hong H;Cai W
正电子发射断层扫描 (PET) 是分子成像领域的一种重要方式，它通过提供安全、快速和可靠的技术逐渐影响患者护理，这些技术通过揭示侵入性、事实上的手术是不必要的或使其过时，有助于改变患者护理的过程。此外，PET 还提供了疾病病理生理学分子机制与相应靶向治疗之间的关键联系。最近，PET 成像在药物输送领域也取得了进展。目前的药物递送研究主要集中在开发新型药物递送系统，重点是精确靶向、准确的剂量递送和最小的毒性，以实现最大的治疗效果。在 PET 成像和受控药物输送之间的交叉领域，人们对将这两种范例结合到临床有效制剂中的兴趣日益浓厚。 PET 图像引导药物输送通过体内评估药物在目标部位的生物分布和积累以及实时监测治疗结果，具有彻底改变患者护理的巨大潜力。这种方法的预期终点是为创新诊断和治疗策略的优化提供基础支持，这可能有助于“个性化医疗”领域的新兴概念。本综述重点关注 PET 图像引导药物输送的最新发展，并讨论未来发展的有趣机会。迄今为止报告的临床前数据非常有希望，而且很明显，癌症管理中的此类策略有望带来临床可转化的进展，可以对整体诊断和治疗过程产生积极影响，并提高癌症患者的生活质量。
Positron emission tomography (PET) is an important modality in the field of molecular imaging, which is gradually impacting patient care by providing safe, fast, and reliable techniques that help to alter the course of patient care by revealing invasive, de facto procedures to be unnecessary or rendering them obsolete. Also, PET provides a key connection between the molecular mechanisms involved in the pathophysiology of disease and the according targeted therapies. Recently, PET imaging is also gaining ground in the field of drug delivery. Current drug delivery research is focused on developing novel drug delivery systems with emphasis on precise targeting, accurate dose delivery, and minimal toxicity in order to achieve maximum therapeutic efficacy. At the intersection between PET imaging and controlled drug delivery, interest has grown in combining both these paradigms into clinically effective formulations. PET image-guided drug delivery has great potential to revolutionize patient care by in vivo assessment of drug biodistribution and accumulation at the target site and real-time monitoring of the therapeutic outcome. The expected end point of this approach is to provide fundamental support for the optimization of innovative diagnostic and therapeutic strategies that could contribute to emerging concepts in the field of “personalized medicine”. This review focuses on the recent developments in PET image-guided drug delivery and discusses intriguing opportunities for future development. The preclinical data reported to date are quite promising, and it is evident that such strategies in cancer management hold promise for clinically translatable advances that can positively impact the overall diagnostic and therapeutic processes and result in enhanced quality of life for cancer patients.
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