How does smoking affect olfaction in Parkinson's disease?
How does smoking affect olfaction in Parkinson's disease?
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DOI：
10.1016/j.jns.2014.02.018
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发表时间：
2014-05-15
影响因子：
4.4
通讯作者：
Pellecchia, Maria Teresa
中科院分区：
文献类型：
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作者：
Moccia, Marcello;Picillo, Marina;Pellecchia, Maria Teresa
烟雾引起的上呼吸道损伤和帕金森病（PD）可被视为嗅觉障碍的独立危险因素。有趣的是，吸烟与帕金森病风险降低密切相关，因此被认为具有神经保护作用。我们的初步研究旨在评估帕金森病患者和匹配对照者中吸烟与嗅觉之间的关系。根据帕金森病诊断和当前吸烟状况对 68 名帕金森病患者和 61 名健康对照者进行分类，并通过意大利版宾夕法尼亚大学 40 项气味识别测试 (UPSIT-40) 进行评估。事后 Bonferroni 校正的方差分析显示，非吸烟者对照者的 UPSIT-40 总分高于吸烟者对照者 (p < 0.001)、非吸烟 PD 患者 (p < 0.001) 和吸烟 PD 患者 (p < 0.001)。从这个观点来看，吸烟似乎会影响对照组的嗅觉，但不会影响帕金森病患者的嗅觉，并且在比较吸烟者对照、吸烟者帕金森病患者和非吸烟帕金森病患者时，没有发现显着差异。一些流行病学研究表明，吸烟对普通人群的嗅觉有负面影响。除此之外，吸烟者和不吸烟的帕金森病患者的嗅觉相似。这些结果表明帕金森病和吸烟并不是嗅觉受损的独立危险因素，但它们可能存在不同程度的相互作用。 (C) 2014 Elsevier B.V. 保留所有权利。
Smoke-induced upper airway damage and Parkinson's disease (PD) can be considered independent risk factors for smell impairment. Interestingly, cigarette smoking has been strongly associated with reduced risk of PD and, therefore, has been suggested to have neuroprotective effects. Our pilot study aimed to evaluate the relationship between smoking and olfaction in PD patients and matched controls.Sixty-eight PD patients and 61 healthy controls were categorized in relation to PD diagnosis and current smoking status, and evaluated by means of the Italian version of the University of Pennsylvania 40-item Smell Identification Test (UPSIT-40).ANOVA analysis with post-hoc Bonferroni correction showed that non-smoker controls presented a higher UPSIT-40 total score than smoker controls (p < 0.001), non-smoker PD patients (p < 0.001) and smoker PD patients (p < 0.001). In this view, smoking seems to affect olfaction in controls but not in PD patients, and no significant differences were found when comparing smoker controls, smoker PD patients' and non-smoker PD patients.Several epidemiological studies showed a negative effect of smoking on olfaction in the general population. Otherwise the sense of smell is similar in smoker and non-smoker PD patients. These results suggest that PD and smoking are not independent risk factors for impairment of sense of smell, but they might variably interact. (C) 2014 Elsevier B.V. All rights reserved.